Business Type: Manufacturer/Factory
Wuhan, Hubei, China
|Other Name||GS5734 metabolite|
If a cat's immune system is healthy and mature, the white blood cells should fight off an infection or virus, and allow the cat to build up an immune response, or antibodies. Cats who develop FIP have an immune defect or deficiency that causes the white blood cells to replicate, rather than fight, the virus. Essentially, the cats immune system is spreading the virus throughout the cat's body rather than trying to eliminate it. Cats who have no immune response develop wet FIP, while cats who have a partial immune response develop dry FIP.
The nucleoside analog GS-441524 is a molecular precursor to a pharmacologically active nucleoside triphosphate molecule. These analogs act as an alternative substrate and RNA-chain terminator of viral RNA dependent RNA polymerase. In layman's terms, GS441 interjects itself into the chain reaction and stops the replication of the virus.
Course of GS441 Treatment
Dr Pedersen's case study determined that a successful course of treatment with GS441 is 12 weeks, administered daily. Some owners have stopped treating once blood work and diagnostics returned to normal; however, the few cats who did relapse were among those who stopped prior to the 12 week protocol. Because the course of treatment is both emotionally and financially taxing, most owners currently using GS opt to pursue the full 12 weeks, to ensure the highest probability of success. Cats who undergo the full 12 weeks and remain symptom-free for 90 days following conclusion of treatment are officially cured of FIP.
GS441 comes in both injectable form, and as of June 2019, a pill form. Both are administered daily and the dose is based on the weight of the cat.
For wet & dry FIP without neurological or ocular symptoms, the recommended dosage is 5mg (GS) x weight (kg) / GS concentration per 1mL = dose per 24 hr.
Neurological and Ocular FIP cats require 7mg/kg MINIMUM, and can go as high as 10mg/kg for extreme ocular or neurological cases.
A dosing calculator can be found here.
It is important to note that the dosage should not be reduced during the course of treatment, regardless of how well the cat is responding. Conversely, if the cat is not responding to the starting dosage, it is safe to increase. It is also crucial to check the cat's weight often, and adjust the daily dose accordingly.
The only known side effect of GS441 is skin lesions or burns, due to the acidity of the solution (injectable form). For this reason, it is recommended to always clean the cat's skin after giving an injection. Many owners also opt to give oral CBD oil or Hemp oil 30-60 minutes before injecting, to help minimize the stress. Should you opt to do this, it is critical that the product be veterinary grade and the proper dose should be determined by a veterinarian. CBD and/or hemp oil can be fatal to a cat if not administered properly. More commonly, Gabapentin, a mild pain medication can be given orally 60-90 minutes prior to the injection. The vast majority of cats using GS tolerate the injections just fine without the need for any pain medication or sedative.
While we've seen first hand that GS is a miracle drug, it's not the end-all-be-all. You still need to support your cat's well-being while waiting for GS to arrive and until your cat starts to respond to it. Proper supportive care can make all the difference as to whether or not the cat survives. Lack of proper supportive care can cause further complications, up to and including death.
Cats need to consume minimally 200 calories per day and 60 ml of water per day. Anemia needs to be treated, whether via B12 or possibly a transfusion, depending on severity. Fluids may need to be drained. Fevers need to be monitored and reduced. For additional information about crucial home care and supportive care of FIP cats, please continue here.
Supplemental Care When Using GS441 to Cure FIP
In general, unless the cat has a secondary or underlying condition besides FIP, all prescription medications can be stopped once treatment with GS begins. However, all cats, FIP or not, can benefit from a high quality probiotic such as Fortiflora. A healthy gut is essential in fighting FIP and can help stave off so many other illnesses too.
For additional information on overall wellness and support, please view the vitamins and supplements page.
We understand that there are many reasons why someone may not want to use GS441. While it is highly effective, it is also still experimental and in many circumstances, cost prohibitive.
For those who wish to provide palliative treatment to their FIP cat, there are several options available.
Polyprenyl Immunostimulant, or "PI" as it is commonly referred to in the FIP groups, is an oral supplement that is administered daily for 1-2 weeks, then every other day once the jump-start dose is completed. PI is approved to treat feline herpes; however, it is used off-label to treat feline infectious peritonitis. It is not a cure of FIP, but there have been some long term FIP survivors. PI is best suited for dry FIP, and the success rate (defined as surviving 1 year or more) is approximately 10%.
Polyprenyl is used to enhance and strengthen the cat's immune system, ideally to allow the cat to fight off the virus.
Cats who are using Polyprenyl should also be receiving overall systemic support by way of weekly B12 injections, daily B12 supplements, and if and as needed, appetite stimulants and ant-nausea medication. Typically an anti-viral medication will also be prescribed for 10-14 days.
PI must be prescribed and ordered by a veterinarian. The necessary forms and ordering information can be found on Vet Immune's website.
*Cats who are taking Polyprenyl for FIP should NOT be taking steroids, as steroids will weaken the cat's immune system and work against the PI.
Steroid Treatment for FIP
For many years, steroid treatment was the only option for FIP cats. It is entirely palliative in nature, i.e. it's purpose is to keep the cat comfortable for however much time he/she has left.
Steroids are inexpensive and can help provide temporary comfort to an FIP cat by increasing appetite, reducing fever, reducing inflammation, and with wet FIP, steroids may also help to reduce the effusion.
Home Care/Supportive Care
The success of palliative care, as well as your cat's quality of life, depends highly on supportive care and treating symptoms such as inappetence, fever, anemia, diarrhea and more. Please continue reading about supportive care here.
Q1: Have your Product Quality been Approved by the Third Party Lab?
A: Yes, all the products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France etc. So you will be assured with Good Quality if you choose us.
Q2: How do you treat quality complaint?
A: First of all, our QC department will do the strict examination of our export products by HPLC, UV, GC ,
TLC and so on in order to reduce the quality problem to near zero. If there is a real quality problem, caused by us, we will send you free goods for replacement or refund your loss.
Q3: Do you Accept Sample Order?
A: Yes, we can accept small order from 10g, 100g and 1kg for your evaluation quality of our goods.
Q4: Is there any discount?
A: Yes, for the larger quantity, we always support with better price for our further cooperation.
Q5: Do you accept VISA business credit card?
A: Sorry we don't accept VISA credit card, but we'd like to accept the bank transfer, Western Union, Paypal or Bitcoin.
Q6: How long does it take the goods to arrive?
It is Depending on your location,
For the small order, please expect the 5-7 days by DHL,UPS,TNT, FEDEX, EMS and so on.
For the mass order, please allow the 5-8 days by Air or 20-35 days by Sea.
Q7: Do you have any reshipment policy?
Of course, we have the good after-sale service and re-shipment policy if the parcel lose.
Our long association with our clients has brought great benefits, we always take the upmost care in the packaging of our products. Our clients will confirm this as even they struggle to find them without help at times.
But in spite of our best efforts, it is still possible will seize a small number of packages. In this circumstance we promise reship free to establish a long term relationship with each other.
Q8: Can I get a sample?
A: Of course. For most products, we can provide you a free sample to test the quality, while the shipping cost should be undertook by your side.
We have formed a technology and management team that cooperate closely with some overseas Labs all speak highly of our safe shipping and goods.
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