GLP-1 Wholesale.
Semaglutide, Tirzepatide, Retatrutide, NAD, GHK-CU, Melanotan, Polypeptide
5mg 10mg 15mg 20mg 30mg 1g
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Common Name |
Semaglutide acetate salt |
CAS Number |
910463-68-2 |
Molecular Weight |
4113.57754 |
Density |
N/A |
Boiling Point |
N/A |
Molecular Formula |
C187H291N45O59 |
Melting Point |
N/A |
MSDS |
N/A |
Flash Point |
N/A |
Semaglutide is a lipopeptide with a linear sequence of 31 amino acids. Like human Glucagon-like peptide-1 (GLP-1), it is used in combination with diet and exercise in the therapy of type 2 diabetes mellitus. It works as an anti-obesity agent, a neuroprotective agent, and an appetite depressant.
Semaglutide can be commercialized as a synthetic generic product after approval of an abbreviated new drug application (ANDA) or comparable applications with other regulatory authorities. The length and modifications make technical excellence and regulatory expertise a prerequisite for efficient filing and fast approval. High material quality and yield, robust processes including secure supply and innovative approaches at high-tech facilities will enable our customers to achieve their business goals.
CERTIFICATE OF ANALYSIS
Product Name |
Semaglutide |
Sample Source |
Workshop 106 |
Batch Number |
LX106S2305107 |
Packing Size |
131.03g/bag, 401.6g/bag, 477.57g/bag |
Quantity |
1010.2g |
Manufacturing Date |
Apr-10-2023 |
Number of Packages |
3 |
Retest Date |
Apr-09-2025 |
Sample Date |
Apr-28-2023 |
Report Date |
May-08-2023 |
Testing Reference |
QC-03-1003-02, QC-02-1595-03 |
TEST ITEM |
SPECIFICATION |
TEST RESULT |
Appearance |
White or almost white loose powder |
white loose powder |
Solubility |
Freely soluble in water, soluble in DMF at 1 mg/mL, 30 mg/mL in DMSO, 0.2 mg/ml in a 1:4 solution of DMSO:PBS |
conforms |
Identification (MS) |
4111.12±0.5Da |
4111.15 |
Identification (HPLC) |
Examine the chromatograms obtained in the assay. The principal peak in the chromatogram obtained with the test solution is similar in retention time and size to the principal peak in the chromatogram obtained with reference solution. |
conforms |
Specific Optical Rotation [α]20D (anhydrous substance) |
-6.0° to -16.0° |
-10.3° |
Purity (HPLC) |
NLT 98.0% |
99.47% |
Water Content |
NMT 8.0% |
3.9% |
pH |
7.0 to 9.0 |
7.9 |
Solution Clarity and Color |
Clear and colorless |
conforms |
Acid Group Ions |
Trifluoroacetate ion NMT 0.1% |
N.D. |
Phosphate ion NMT 0.1% |
N.D. |
Chloride ion NMT 0.1% |
0.003% |
Acetate ion NMT 0.1% |
N.D. |
Sodium Ion |
NMT 4.0% |
2.1% |
Related Substances I |
SPEC054-Z18 NMT 0.50% |
N.D. |
SPEC054-Z20 NMT 0.30% |
0.03% |
SPEC054-Z21 NMT 0.50% |
N.D. |
SPEC054-Z57 NMT 0.20% |
N.D. |
Any other impurities NMT 0.10% |
0.02% |
Total impurities NMT 1.0% |
0.08% |
Related Substances II |
SPEC054-Z19 NMT 0.30% |
0.02% |
SPEC054-Z23 NMT 0.20% |
0.03% |
SPEC054-Z69 NMT 0.20% |
N.D. |
Total related substances I and II NMT 1.50% |
0.12% |
Amino Acid Analysis |
Asp:0.8-1.2 |
1.1 |
His:0.8-1.2 |
1.0 |
Tyr: 0.8-1.2 |
1.2 |
Lys: 0.8-1.2 |
1.0 |
Ile: 0.8-1.2 |
1.0 |
Aib: 0.8-1.2 |
0.8 |
Leu: 1.6-2.4 |
2.2 |
Val: 1.6-2.4 |
2.1 |
Arg: 1.6-2.4 |
2.0 |
Thr: 1.6-2.4 |
1.9 |
Phe: 1.6-2.4 |
1.9 |
AEEA: 1.6-2.4 |
1.7 |
Ser: 2.4-3.6 |
2.8 |
Ala: 2.4-3.6 |
3.0 |
Gly: 3.2-4.8 |
4.0 |
Glu: 4.0-6.0 |
5.2 |
Trp (Partially destroyed during acid hydrolysis) |
detected |
Residual Solvents |
Acetonitrile NMT 410ppm |
N.D. |
Isopropyl ether NMT 5000ppm |
N.D. |
Methylene chloride NMT 600ppm |
N.D. |
Pyridine NMT 200ppm |
N.D. |
DMF NMT 880ppm |
N.D. |
TIS NMT 1000ppm |
N.D. |
1,2-Ethanedithiol NMT 1000ppm |
N.D. |
DIC NMT 1000ppm |
N.D. |
DIEA NMT 1000ppm |
N.D. |
Piperidine NMT 100ppm |
N.D. |
Bacterial Endotoxins |
2 EU/mg |
< 2 EU/mg |
Microbial Limits |
Total aerobic microbial count NMT 100 cfu/g |
< 10 cfu/g |
Total yeasts and molds count NMT 50 cfu/g |
< 10 cfu/g |
Escherichia coli count |
Absent in 1g |
Conclusion: This batch of product COMPLIES with the prescribed standards. |
Storage condition: -20°C ± 5°C, well-closed containers, protected from light. |
How is Retatrutide different from Semaglutide and Trizepatide ?
Mechanism:
1. Semaglutide work as (GLP-1) hormone agonist.
2. Tirezepatide work as (GLP-1 & GIP ) hormone agonist.
3. Retatrutide work as (GLP-1 & GIP & Glucagon) hormones agonist.
Weight loss in trials:
1. Semaglutide led to a 6-12% reduction in body weight in 28 weeks
2. Tirezepatide led to a 15-20% reduction in body weight in 72 weeks
3. Retatrutide led to a 25% reduction in body weight in 48 weeks
Weight Management
Indicated as an adjunct to a reduced calorie diet and increased physical activity for chronic weight management in adults with an initial body mass index (BMI) of ≥30 kg/m2 (obesity) or ≥27 kg/m2 (overweight) in the presence of at least 1 weight-related comorbid condition (eg, hypertension, type 2 diabetes mellitus, dyslipidemia)
Initiate with low dose and gradually escalate to maintenance dose of 2.4 mg/week SC to minimize GI adverse reactions
If unable to tolerate a dose during escalation, consider delaying dose escalation for 4 weeks
If unable to tolerate maintenance dose of 2.4 mg once-weekly, may temporarily decreased to 1.7 mg once weekly, for a maximum of 4 weeks; after 4 weeks, increase back to maintenance 2.4 mg once-weekly; discontinue if not tolerated after second attempt
In patients with type 2 diabetes, monitor blood glucose before initiating and during treatment
Once weekly SC dose escalation schedule:
Weeks 1-4: 0.25 mg
Weeks 5-8: 0.5 mg
Weeks 9-12: 1 mg
Week 13-16: 1.7 mg
Week 17 and onward: 2.4 mg (maintenance)
Product No. |
Product |
45051511 |
Semaglutide 5mg |
45051512 |
Semaglutide 10mg |
45051513 |
Semaglutide+Vitamin B12 |
45051514 |
Semaglutide+Vitamin B6 |
45051515 |
Semaglutide+L-Carnitine |
45051516 |
Semaglutide cartridges 5mg |
45051517 |
Semaglutide cartridges 10mg |
45051518 |
Setmelanotide 20mg |
45051519 |
Tirzepatide 5mg |
45051520 |
Tirzepatide 10mg |
45051521 |
Tirzepatide 15mg |
45051522 |
Tirzepatide 20mg |
45051523 |
Tirzepatide 30mg |
45051524 |
Tirzepatide+Vitamin B12 |
45051525 |
Liraglutide 10g |
45051526 |
Retatrutide 8mg |
45051527 |
Retatrutide 10mg |
45051528 |
Retatrutide 12mg |
45051529 |
Orforglipron 1g |
45051530 |
Mazdutide 1g |
45051531 |
NAD+ 500mg |
45051532 |
NAD+ 750mg |
45051533 |
NAD+ 1000mg |
45051534 |
NMN 150mg |
45051538 |
Adipotide/FTPP 10mg |
45051539 |
α-Klotho (Alpha Klotho) 50µg |
45051541 |
A960 5mg |
45051542 |
ARA-290 16mg |
45051543 |
57 5mg |
45051544 |
57 10mg |
45051545 |
B7-33 5mg |
45051546 |
cAC-253 (Cyclic AC-253) 10mg |
45051549 |
DSIP 5mg |
45051550 |
DSIP 10mg |
45051551 |
Epitalon 10mg |
45051552 |
Epitalon 20mg |
45051553 |
Epitalon 100mg |
45051554 |
FG loop (FGL) 10mg |
45051556 |
F344 1mg |
45051557 |
FOXO4-DRI 10mg |
45051559 |
GHK-Cu (Copper Peptide) 50mg |
45051560 |
GHK-Cu (Copper Peptide) 100mg |
45051561 |
G2 10mg |
45051562 |
G6 10mg |
45051563 |
Gona 10mg |
45051564 |
HC5000 |
45051565 |
Hexa 2mg |
45051566 |
Hexa 5mg |
45051568 |
Humanin 10mg |
45051573 |
Ipam 5mg |
45051575 |
Kisspeptin-10 5mg |
45051576 |
Kisspeptin-10 10mg |
45051577 |
KPV 5mg |
45051578 |
KPV 10mg |
45051579 |
LL-37 (CAP-18) 5mg |
45051580 |
Melanotan 1 10mg |
45051581 |
Melanotan 2 10mg |
45051582 |
MOTS-c 5mg (acetate, TFA removed) |
45051583 |
MOTS-c 10mg (acetate, TFA removed) |
45051584 |
N-Acetyl Epitalon Amidate 10mg |
45051585 |
N-Acetyl Selank Amidate 10mg |
45051586 |
N-Acetyl Semax Amidate 30mg |
45051587 |
Oxytocin 10mg |
45051588 |
PNC-27 5mg |
45051590 |
P21 (P021) 5mg |
45051591 |
Selank 10mg |
45051592 |
Semax 10mg |
45051593 |
Sermo 2mg |
45051594 |
Sermo 5mg |
45051595 |
SS-31 40mg |
45051596 |
Taltirelin 10mg |
45051597 |
Tesam 2mg |
45051598 |
Tesam 5mg |
45051600 |
Thymalin 20mg (63958-90-7) |
45051601 |
Thymosin Alpha-1 3mg |
45051602 |
Thymosin Alpha-1 5mg |
45051603 |
Thymosin Alpha-1 10mg |
45051604 |
Thymosinb4 5mg |
45051605 |
Thymosinb4 10mg |
45051607 |
TP508 Thrombin Peptide 10mg |
45051608 |
TRH Thyrotropin (Protirelin Acetate) 20mg |
45051609 |
VIP (Vasoactive Intestinal Peptide) 6mg |
45051610 |
Bronchogen (Bronchi) 20mg |
45051611 |
Cardiogen (Myocardium) 20mg |
45051612 |
Cartalax (Joints) 20mg |
45051613 |
Chonluten (Respiratory organs) 20mg |
45051614 |
Cortagen (Brain) 20mg |
45051615 |
Crystagen (Immune system) 20mg |
45051616 |
Livagen (Liver) 20mg |
45051617 |
Pancragen (Pancreas) 20mg |
45051618 |
Pinealon (Brain) 20mg |
45051619 |
Prostamax (Prostate) 20mg |
45051620 |
Testagen (Testes) 20mg |
45051621 |
Vesugen (Blood vessels) 20mg |
45051622 |
Vilon (Eye retina) 20mg |
45051623 |
B15, T50 Blend 10mg |
ZB Bio has a long-standing track record in with successful registrations of highly purified synthetic peptide drugs of the glucagon family. Our regulatory intelligence keeps track of important changes in the relevant legislation. This enables us to be a leading global innovator in the field of glucagon and glucagon-like synthetic peptide drugs. Our services have been optimized to shorten timelines and of reduce complexity for our clients.
Our high-tech Good Manufacturing Practice (GMP) facilities based in Zhejiang province china, plus the commitment of our technical and scientific experts to quality, are the cornerstones for continuous compliance. We deliver small-scale to multi-kg active pharmaceutical ingredients (APIs) with impurities below 0.5%, identification and characterization of impurities above 0.10% using orthogonal analytical techniques.
OPTIMIZED, AUTOMATED HIGH-YIELD PRODUCTION
Our long experience in complex APIs allows us to optimize the processes for high yields at outstanding quality. Our high level of process automation allows for cost-efficient and large-scale production resulting in excellent overall material purity (>99.5%). Innovative solutions like continuous chromatography let us use equipment and resources more efficiently and help us and our partners to achieve their commitment to sustainability and environment-friendly production.
OUR TIMELINES FOR SEMAGLUTIDEROBUST PROCESSES AND SUPPLY SECURITY
Having our in-house building blocks for peptide synthesis as well as long-term cooperation with trusted suppliers ensures on-time production. Redundancy of multi-purpose equipment and facilities helps to mitigate risks in the supply chain, together with our stock of finished APIs and is the key for on-time product deliveries to our customers.
RELATED PRODUCTS (FOR RESEARCH PURPOSES ONLY)
Beyond GMP-grade semaglutide, we provide semaglutide in research grade, variants thereof and in different salt forms.