| CAS No.: | 126229-12-7 |
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| Formula: | C35h40cl2n4o6 |
| EINECS: | N/a |
| Type: | Organic Intermediate |
| Appearance: | Powder |
| Quality: | Industrial |
| Samples: |
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| Customization: |
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| Product Name | Top Quality Antihypertensive Manidipine Hydrochloride Powder CAS 126229-12-7 Manidipine HCl |
| Appearance | powder |
| Molecular formula | C35H40Cl2N4O6 |
| Molecular Weight | 683.6213 |
| Keywords | Manidipine HCl;Manidipine HCl Powder;Manidipine Hydrochloride |
| Shelf Life | 24 months when properly stored |
| Storage | Keep in a cool, dry, dark location |
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What is Manidipine hcl? Manidipine Dihydrochloride is a metabolite of Manidipine (M16400), a dihydropyridine calcium channel blocker that exhibits antihypertensive properties. Manidipine 2Hcl (CV-4093) is a dihydropyridine compound and a calcium channel blocker for Ca2+ current with IC50 of 2.6 nM. IC50 value: 2.6 nMTarget: calcium channelManidipine is described to block T-type Ca2+ channels specifically and is also described to have a high selectivity for the vasculature, presenting negligible cardiodepression as compared to other Ca2+ channel antagonists. Manidipine is also described to not significantly affect norepinephrine levels, suggesting a lack of sympathetic activation with this compound. Manidipine reduces pro-inflammatory cytokines secretion in human endothelial cells and macrophages. Manidipine, unlike other third-generation dihydropyridine derived drugs, blocks T-type calcium channels present in the efferent glomerular arterioles, reducing intraglomerular pressure and microalbuminuria.. |
Manidipine dihydrochloride is a dihydropyridine compound and calcium channel protein inhibitor and antagonist. Manidipine is described to block T-type Ca2+ channels specifically and is also described to have a high selectivity for the vasculature,presenting negligible cardiodepression as compared to other Ca2+ channel antagonists. Manidipine is also described to not significantly affect norepinephrine levels, suggesting a lack of sympathetic activation with this compound.
High quality Material cas 120092-68-4 raw Manidipine/Manidipine hcl price
Q: What's your MOQ ?
A: For the high value product, our MOQ starts from 1g and generally starts from 10gs. For other low, price product, our MOQ starts from 100g and 1kg.
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