Pharmaceutical Intermediates Chemical Powder for Treat Oronary Heart Disease CAS 21829-25-4 Nifedipine

Descritpion:
Nifedipine is a dihydropyridine calcium antagonist, can inhibit myocardial and vascular smooth muscle on the Ca 2+ uptake, expandthe coronary artery, increase coronary blood flow, improve the heart muscle Ischemia tolerance, while it can expand the surrounding arterioles, reduce peripheral vascular resistance, relieve coronary spasm, increase coronary flow, improve myocardial hypoxia, and thus reduce blood pressure. Low-dose coronary dilation does not affect blood pressure, and is a good anti-angina drug. For the prevention and treatment of coronary heart disease angina, no adverse effects on respiratory function, especially for angina caused by coronary artery spasm and angina pectoris with the best effect of respiratory obstructive disease, its
efficacy is better than β-blockers. It is also suitable for various types of hypertension, including severe and refractory
hypertension.

Treatment of intractable congestive heart failure can be long-term use of this product. Also used to treat primary pulmonary hypertension, diffuse esophageal spasm and bronchial asthma, duodenal ulcer, urinary tract obstruction , exercise asthma,achalasia and so on.
Nifedipine has certain selectivity for vascular smooth muscle, and its direct negative inotropic and degenerative effects on the heart are weak. Therefore, systemic administration does not cause heart rate to slow down and manifests as increased heart rate reflex.