Penicillin Antibiotics 99% Purity API Azlocilin Sodium Powder with CAS 37091-65-9

Aloxicillin sodium

Chinese alias: imipenecillin sodium; Azolone ampicillin; (2S, 5R, 6R) - 3,3-dimethyl-6 - [[[[(2-oxo-1-imidazolyl) carbonyl] amino] Phenylacetyl] amino] - 7-oxo-4-thia-1-azabicyclo [3,2,0] heptane-2-carboxylic acid sodium salt

English Name:

English alias: azlocillin; sodium (2R,5S,6S)-3,3-dimethyl-7-oxo-6-{[(2R)-2-{[(2-oxoimidazolidin-1-yl)carbonyl]amino}-2-phenylacetyl]amino}-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate; (2S,5R,6R)-3,3-dimethyl-7-oxo-6-{[(2S)-2-{[(2-oxoimidazolidin-1-yl)carbonyl]amino}-2-phenylacetyl]amino}-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; sodium (2S,5R,6R)-3,3-dimethyl-7-oxo-6-{[(2S)-2-{[(2-oxoimidazolidin-1-yl)carbonyl]amino}-2-phenylacetyl]amino}-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate

EINECS:253-347-7

Molecular formula: c20h22n5nao6s

Molecular weight: 483.4733

Pharmacology and application editing and broadcasting

Aloxicillin sodium structural formula

Aloxicillin sodium structural formula

This product is a penicillin antibiotic. It is the third generation of broad-spectrum semi synthetic penicillin. It is effective against G + bacteria, G-bacteria and anaerobic bacteria, and can strongly resist Pseudomonas aeruginosa. It is applicable to the infection caused by G + bacteria, G-bacteria and anaerobic bacteria. Effective for Pseudomonas aeruginosa infection!!

Function and purpose editing and broadcasting

The antibacterial spectrum of this product is similar to that of mezlocillin sodium. The product is not resistant to penicillinase produced by Staphylococcus aureus and Enterobacteriaceae β- Lactamase. The drug resistance of Pseudomonas aeruginosa to this product sometimes develops rapidly. The combination of aminoglycosides and this product can strengthen the effect on Pseudomonas aeruginosa and some other gram-negative bacteria.

Editing and broadcasting of indications

Various infections caused by sensitive Gram-negative and positive bacteria, as well as Pseudomonas aeruginosa infections, including sepsis, meningitis, endocarditis, suppurative pleurisy, peritonitis, lower respiratory tract, gastrointestinal tract, biliary tract, kidney and ureter, bone, soft tissue and reproductive organ infections, gynecological and obstetric infections, otitis externa, burns, skin and surgical infections.

Usage editing broadcast

Aloxicillin sodium injection

Aloxicillin sodium injection

Intravenous injection or intravenous drip: 2 ~ 4G / time, dissolved and diluted with infusion, once every 4 hours. Intravenous injection should be slow (more than 5 minutes). Adults 4-6 g / day, severe cases can be increased to 10-16 g / day, divided into 2-4 intravenous drops, children 75 mg / kg body weight / day, divided into 2-4 intravenous drops, infants 100 mg / kg body weight / day, divided into 2-4 intravenous drops. Mild infection (such as urethritis without complications): 100-125mg / kg per day, 2G per time for adults, once every 6 hours.

Moderate infection: 150-200mg / kg per day, 3G per time for adults, once every 6 hours.

Severe infection: 225-300mg / kg per day. Adults can use 3G every 4 hours or 4G every 6 hours.

Dosage for patients with impaired renal function: normal dosage for patients with creatinine clearance rate > 30ml / min. 10-30ml / min: 1.5g for mild infection every 12 hours; For moderate infection, 1.5g per time, once every 8 hours; For severe infection, 2G per time and once every 8 hours< 10ml / min; For mild infection, 1.5g per time, once every 12 hours; For moderate infection, 2G per time, once every 12 hours; Severe infection is 3G per time and once every 12 hours. Children's dosage should be reduced.

Precautions: edit and broadcast

It is forbidden for those who are allergic to penicillin. Patients with allergic quality should use it with caution. For patients with decreased renal function, the dose should be appropriately reduced.

Editing and broadcasting of conformity inspection

The clarity and color of the solution shall be 5 bottles. After each bottle is dissolved with 5ml of water (calculated according to the marked amount of 0.5g), the solution shall be clear and colorless; If it is turbid, it shall not be concentrated compared with No. 1 turbidity standard solution (Appendix 58, Part II, Chinese Pharmacopoeia, 1990 edition); If the color is developed, it shall not be deeper than the yellow green or Yellow No. 3 standard colorimetric solution (method 1 on page 57 of Appendix 2 of Chinese Pharmacopoeia, 1990 edition). Water shall be separated and determined according to the moisture determination method (the first method on page 55 of Appendix 2 of Chinese Pharmacopoeia, 1990 edition). The moisture content shall not exceed 2.5%. No less than 2 bottles shall be taken aseptically and checked according to the method under aloxicillin sodium, which shall meet the requirements. The pH, abnormal toxicity and pyrogen shall be checked according to the method under aloxicillin sodium, which shall meet the regulations. Others shall comply with relevant provisions under injections (Appendix 5, Part II, Chinese Pharmacopoeia, 1990 edition).

Adverse reaction editing and broadcasting

This product can cause anaphylactic shock. An allergy test should be carried out before use.

Gastrointestinal reactions may occur, such as nausea, vomiting, abdominal distension, diarrhea, loss of appetite, etc., which are more common in oral administration. Others have phlebitis. High dose application can lead to nervous system reactions, such as convulsions, spasms and unconsciousness. Individual aminotransferase increased.

Allergic reactions such as drug and drug fever can also be seen. A few people can have secondary infection of Candida albicans.