Oral Anticoagulants USP/Ep/Cp Rivaroxaban for Blood Clotting
Rivaroxaban is an anticoagulant medication (blood thinner), which is taken by mouth. It is commonly used to prevent blood clots. Rivaroxaban is the first available active direct factor Xa inhibitor which is taken by mouth. The maximum inhibition of factor Xa occurs four hours after a dose. The effects last approximately 8-12 hours, but factor Xa activity does not return to normal within 24 hours, so once-daily dosing is possible.
In those with non-valvular atrial fibrillation it appears to be as effective in preventing nonhemorrhagic strokes and embolic events. Rivaroxaban is associated with lower rates of serious and fatal bleeding events though rivaroxaban is associated with higher rates of bleeding in the gastrointestinal tract.
Testing Item |
Standard |
Result |
Appearance |
White or almost white crystalline powder |
Complies |
Solubility |
slightly soluble in glacial acetic acid, practically in soluble in ethanol or water |
Complies |
Identification 1: |
UV: The wavelength of maximum absorption should be at 248nm, 200nm; minimum absorption at 220nm. |
Complies |
Identification 2: |
IR: The IR absorption spectrum of sample corresponds to that of the reference one. |
Complies |
Identification 3: |
HPLC: The retention time of major peak in the test solution corresponds to the peak of Rivaroxaban in racemate reference solution |
Complies |
Melting Point |
228°C ~ 232°C |
229°C ~ 231°C |
Specific Optical Rotation |
-46° ~ -51° |
-48.7° |
Chloride |
≤ 0.1% |
< 0.10% |
Loss on drying |
≤ 0.5% |
0.01% |
Residual on Ignition |
≤ 0.1% |
0.01% |
Heavy Metal |
≤ 20ppm |
< 20ppm |
Related Substance: |
Single impurity ≤ 0.1% |
0.06% |
|
Total impurities ≤ 1.0% |
0.13% |
Enantiomer |
≤ 1.0% |
< 0.03% |
Assay (Purity) |
98.0% ~ 101.0% |
99.90% |
Q1:Can I get some samples?
A: Yes, we can supply the free sample,customer only need bear the shipping cost.
Q2:How to start orders or make payments?
A: Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T,Western Union or Paypal or secure payment.
Q3: How about delivery lead time?
A: About 7-10 days after payment confirmed.(Chinese holiday not included).
Q4:Is there any discount?
A: Different quantity has different discount.
Q5: How to ship it?
A: For small order, we would send by express such as Fedex, DHL, etc. For large order, we would send by air or sea.