Hyaluronic Acid
English name:	Sodium hyaluronate
Other names:	Hyaluronic acid sodium salt; Chlamyhyaluronic acid sodium salt
Cas No.:	9067-32-7 & 9004-61-9
Specification:	Cosmetic, food-grade, pharmaceutical grade.
Appearance:	White crystalline powder
Active Ingredient:	Hyaluronic Acid
Molecular Formula:	(C14H20NO11Na)n

Description:
Hyaluronic acid(HA) is a straight-chain macromolecular mucopolysaccharide composed Of repeat disaccharide units of glucuronic acid and N-acetylglucosamine. It widely consists in the extracellular space of human and animal tissue, vitreum, umbilical cord, skin joints synovia and cockscomb, etc. The commercial HA is commonly a sodium salt, called sodium hyaluronate, habitually called hyaluronic acid. HA is a new biological at home and abroad. Its molecular weight is from several ten thousand to several million. Its aqueous solution has outstanding moisture-keeping ability, high viscoelasticity, and lubricity. It is widely used in cosmetics, pharmacy, and health and beauty food.
Hyaluronic acid(HA) is an important component of articular cartilage, where it is present as a coat around each cell (chondrocyte). when aggrecan monomers bind to hyaluronan in the presence of link protein, large highly negatively-charged aggregates form. these aggregates imbibe water and are responsible for the resilience of cartilage (its resistance to compression). the molecular weight (size) of hyaluronan in cartilage decreases with age, but the amount increases.
Hyaluronan is also a major component of skin, where it is involved in tissue repair. when skin is exposed to excessive UVB rays, it becomes inflamed (sunburn) and the cells in the dermis stop producing as much hyaluronan and increase the rate of its degradation. hyaluronan degradation products then accumulate in the skin after UV exposure.
Efficiency:
1) increase skin elasticity, postpone skin aging. 2)promote the proliferation and differentiation of epidermal cells, removal of oxygen free radicals, 3)prevent and repair skin damage. The hyaluronic acid aqueous solution has a high viscosity 4)make the water phase thickening, And paste evenly after the oil phase emulsification is exquisite, has stable emulsification. Hyaluronic acid is one of the best natural moisturizing ingredients of high-end cosmetics, good compatibility 5)Can be added to almost any beauty cosmetics, widely used in cream, lotion, lotion, essence, cleansers, bath, wash hair, moss, expansion, lipstick, and other cosmetics, the general content is 0.05-0.5%.
Application:
Food supplements: Hyaluronan through the oral administration after the digestion absorption, increases in vivo hyaluronan synthesis the precursor, causes in the skin and other organization's hyaluronan resultant quantity increases, thus enabling the skin the water retention property to increase, rich elasticity, wrinkle reduction.
Medical applications: Hyaluronan could be used in eye surgery, such as corneal transplantation, cataract surgery, glaucoma surgery, and surgery to repair the retinal detachment. Hyaluronan can also be used to treat osteoarthritis of the knee. They are administered as a course of injections into the knee joint, which are believed to supplement the viscosity of the joint fluid, thereby lubricating the joint, cushioning the joint, and producing an analgesic effect. Hyaluronan has also been used in the synthesis of biological scaffolds for wound-healing applications. These scaffolds typically have proteins such as fibronectin attached to the hyaluronan to facilitate cell migration into the wound. Hyaluronan is also used in anti-adhesive products, which are widely used in pelvic and abdominal surgery to prevent postoperative adhesions.
Cosmetics applications: Hyaluronan has outstanding moisture keeping ability, thus called Natural Moisturing Factor in the world. Hyaluronan is a common ingredient in skin-care products, which can be used as a very effective topical humectant. In 2003, the FDA approved hyaluronan injections for filling soft tissue defects, which can be used for facial wrinkles, lip augmentation, reduction of folds and wrinkles, and removal of scars.
Equine applications: Hyaluronan is used in the treatment of articular disorders in horses, in particular those in competition or heavy work. It is indicated for carpal and fetlock joint dysfunctions, especially used for synovitis associated with equine osteoarthritis. It can be injected directly into an affected joint, or intravenously for less localized disorders. It may cause mild heating of the joint if directly injected, but this does not affect the clinical outcome. intra-articularly administered medicine is fully metabolized in less than a week.

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Hyaluronic Acid

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