Product name |
AMIKACIN |
CAS |
37517-28-5 |
Appearance |
white powder |
Assay |
99% |
Storage |
Cool and Protect from light |
Product Name:AMIKACIN
CAS:37517-28-5
MF:C22H43N5O13
MW:585.6
EINECS:253-538-5
Mol File:37517-28-5.mol
Melting point:203ºC
alpha D23 +99° (c = 1.0 in water)
Boiling point:642.23°C (rough estimate)
Density 1.3764 (rough estimate)
refractive index 1.7500 (estimate)
storage temp. 2-8°C
solubility H2O: 50 mg/mL, clear, colorless
pkapKa 8.1 (Uncertain)
form solid
color white to off-white
Amikacin is made semisynthetically from kanamycin A. Interestingly, the L-hydroxyaminobutyryl amide (HABA) moiety attached to N-3 inhibits adenylation and phosphorylation in the distant amino sugar ring (at C-2′and C-3′), even though the HABA substituent is not where the enzymatic reaction takes place. This effect is attributed to decreased binding to the R factor-mediated enzymes.
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