Cyclopamine (11-deoxojervine) CAS 4449-51-8

Certification:	ISO, HACCP, Halal , Kosher
Assay Method:	HPLC, UV
Application Form:	Tablet, Capsule
Application:	Food, Health Care Products, Medicine
State:	Powder
Mesh Size:	80 Mesh

Samples:	US$ 1/20g 1 20g(Min.Order) \| Request Sample

Customization:	Available \| Customized Request

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Hunan Sunfull Bio-Tech Co., Ltd.

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Basic Info.

Model NO.

SF-CYC001

Transport Package

25kg/Paper Drum

Specification

Trademark

Sunfull

Origin

China

HS Code

2938909090

Production Capacity

2000 Ton/Year

Product Description

Cyclopamine (11-deoxojervine)

Chinese Name Huangbaan
Botanical Resource:     Veratrum californicum or Veratrum nigrum L
CAS No.:              4449-51-8
Molecular formula:     C₂₇H₄₁NO₂
Molecular weight:       411.62
Melting point:      237-238ºC
Specific optical Rotation:[α]²⁰^ºC_D -44.2º
Product Specification   98% Cyclopamine (11-deoxojervine)

Product Introduction
Cyclopamine (11-deoxojervine) is a naturally-occurring chemical that belongs to the group of steroidal jerveratrum alkaloids. It is a teratogen isolated from the corn lily (Veratrum californicum) that causes usually fatal birth defects. It can prevent the fetal brain from dividing into two lobes (holoprosencephaly) and cause the development of a single eye (cyclopia). It does so by suppressing the hedgehog gene (Hh). Cyclopamine is useful in studying the role of Hh in normal development, and as a potential treatment for certain cancers in which Hh is overexpressed.
Physical Properties:
White Powder; Odorless; Melting point:237-238ºC; Solubility:5mg·ml-1 Methanol;10mg·ml-1DMF.
Loss on drying: ≤0.5%

Physiological Functions & Applications
Cyclopamine inhibits the hedgehog signaling pathway (Hh) by influencing the balance between the active and inactive forms of the Smoothened protein.Cyclopamine is currently being investigated as a treatment agent in basal cell carcinoma, medulloblastoma, and rhabdomyosarcoma, tumors that result from excessive Hh activity [2], glioblastoma, and as a treatment agent for multiple myeloma.


HPLC-ELSD Chromatogram of 98% Cyclopamine

LC-MS of cyclopamine

H¹-NMR of cyclopamine in CDCI₃

C¹³-NMR of cyclopamine in CDCI₃

Microbial
Total Plate Count	NMT 1,000cfu/g	Conforms	GB/T 4789.2 -2020
Total Yeast & Mold	NMT 100cfu/g	Conforms	GB/T 4789.15-2020
E. Coli	Negative	Conforms	GB/T 4789.3 -2020
Salmonella	Negative	Conforms	GB/T 4789.4 -2020
Packing & Storage	Pack in paper drum and two plastic bags inside. Net Weight: 25 kg/drum. Store in a well-closed container away from moisture.