Changsha, Hunan, China
Member Since: 2019
Business Type: Manufacturer/Factory,Trading Company
Green Coffee Bean Extract
Product Name: Green Coffee Bean Extract
Botanical Source: Coffea Arabica L.
Part Used: Seed
Specification: Chlorogenic Acid 20%~98%
Appearance: Yellow Fine Powder
Green Coffee Bean Extract is sourced from Europe and is standardized to more than 99% Chlorogenic Acid. Chlorogenic Acid is the compound present in coffee.
Which has been long known as for its beneficial properties. This active ingredient can absorb free oxygen radicals; help to avert hydroxyl radicals in the body.
Along with being a great anti-oxidant, there is evidence that Chlorogenic Acid may have biological effects in the small intestine that alter patterns of glucose uptake, helping to regulate the metabolism.
The Caffeic Acids act as stimulant, providing a safe energy boost while being naturally low in caffeine. Boiled coffee drinks contain cafestol which is associated with the negative effects of using coffee as a stimulant, this is not present in green coffee beans or the extract.
Green Coffee Bean is also great for sports formulations because it can work to stimulate the production of cortisone and adrenalin in the body resulting in increased stamina.
1. Works in two ways as a powerful anti-oxidant reducing free oxygen radicals. 2. Helps to regulate the body's metabolism by inhibiting glucose 6 phosphate. 3. Increases Stamina by stimulating the production of cortisone and adrenalin.
4. Can increase the effectiveness of pain killers, especially for migraine medications.
5. Can help to reduce the risk of diabetes, studies report 30% in women and over 50% in men.
6.Helps the body burn a higher proportion of lipids to carbohydrates, which can help avoid muscle fatigue.
1.In pharmaceutical field
2.In health product field
3.In Cosmetic field
Product Name: Chlorogenic Acid / Eucommia Extract/ Eucommia Ulmoides Extract
Part Used: Bark Leaf
Specification: Chlorogenic Acid 5%-98%, 5:1, 10:1;20:1
Appearance: Brown Yellow Fine Powder
1. Eucommia bark extract is associated with the liver and kidneys, and is considered the primary herb used to increase yang functions in the body.
2. Eucommia bark strengthens the bones and muscles, heals injured and weakened tissues, and can treat lower back and leg pain, stiffness and arthritis.
3. In addition to its healing effects, eucommia has the ability to lower blood pressure; most Chinese formulas used to lower blood pressure contain at least some amount of eucommia.
4. It is also given to pregnant women to calm the fetus and prevent miscarriage.
2. Antibacterial, Antiviral, and Anti-Inflammatory Activity
|Chlorogenic acid Basic information|
|Pharmacological action Protecting liver, gallbladder The inhibitory effect on hyaluronidase and glucose - 6 - phosphatase The character of molecular structure Preparation method HPLC method for determination the content Toxicity Chemical property Uses Category Toxicity grading Acute toxicity Flammability hazard characteristics Storage and transport properties Fire extinguishing agent|
|Product Name:||Chlorogenic acid|
|Synonyms:||(1R,3R,4S,5R)-3-[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy-1,4,5-trihydroxy-cyclohexane-1-carboxylic acid;CHLOROGENID ACID;CHLOROGENIC ACID(AHP);3-CAFFEOLYQUINICACID;3-[[3-(3,4-dihydroxyphenyl)-1-oxy-2-propenyl]oxy]-1,4,5-trihydroxy-1, [1S-(1 a , 3 β , 4 a , 5 a )];Chlorogenic Acid Hydrate;CHLOROGENIC ACID extrapure;Chlorogenic acid,3-Caffeoylquinic acid|
|Product Categories:||Plant Oils, Toxins, Phenolic Acids & Derivatives;Natural Plant Extract;Plant extract;caffeic acid;Chlorogenic acid;The group of Chlorogenic acid;Plant extracts;Herb extract;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;natural product;Inhibitors|
|Chlorogenic acid Chemical Properties|
|Melting point||210 °C (dec.)(lit.)|
|alpha||-36 º (c=1, H2O)|
|Boiling point||407.55°C (rough estimate)|
|density||1.3594 (rough estimate)|
|refractive index||-37 ° (C=1, H2O)|
|solubility||Soluble in ethanol and acetone.|
|form||Powder, Crystals, Needles and/or Chunks|
|color||White to almost white|
|Water Solubility||SOLUBLE IN HOT WATER|
|CAS DataBase Reference||327-97-9(CAS DataBase Reference)|
|EPA Substance Registry System||Chlorogenic acid (327-97-9)|
|Toxicity||LDLo intraperitoneal in rat: 4gm/kg|
|Chlorogenic acid Usage And Synthesis|
|Pharmacological action||Chlorogenic acid is also called "green" auspicious acid, tannins "coffee", "coffee tannic acid", is a plant produce a styrene acrylic compounds through shikimic acid hitches in aerobic respiration process.It is coffee acyl quinic acid derivatives.The oxidation resistance is strong, and also has the anti HIV, anti tumor cells, antibacterial, improve central excited, cholagogue function.It has teratogenic, allergy and regulate the activity of cytochrome P450 ligase, and other functions.It is widely exist in more content honeysuckle plants. It is obtained by the water needle crystal, and it is the hemihydrate, when 110 ºC it is to hydrate. Melting point is 208 ºC, [a] D25 33.5 ° (water, C = 1), K = 2.2 x 10-3 (27 ºC).It is weak acidity and convergence. When 25 ºC , the solubility in water is 4%, easily soluble in hot water, but soluble in ethanol, acetone, slightly soluble in ethyl acetate, insoluble in chloroform, ether and carbon disulfide. It is azeotropic with concentrated hydrochloric acid and come to blue dye. It can make the bromine water fade, It is azeotropic with strong hydrogen iodide and obtain benzoic acid, It is obtained phenol by thermal decomposition together with water at 230 ºC, It decomposite to caffeic acid and quinic acid with dilute hydrochloric acid, and caffeic acid and quinic acid with dilute alkali at room temperature. Chlorogenic acid and its isomer different chlorogenic acid and green chlorogenic acid are in fruits of dicotyledonous plants, leaves, and other organizations,which is an important factor for plant metabolism. Chlorogenic acid has good biological activity, the transparent acid enzyme and inhibition of glucose-6-phosphatase, free radical lipid perxidation qing mutagenesis resistance and cardiovascular crown reinforcement, special efficacy in lipid-lowering, both anti-bacterial anti-virus, protecting liver cholagogic.|
Chlorogenic acid as the condensation product of caffeic acid and quinic acid, is blue when meeting with iron, which is similar to tannins , but not precipitated with protein, so no convergence. Caffeic acid and chlorogenic acid has the wide bacteriostasis, but can be inactivated protein in the body. This product is similar to caffeine, oral or intraperitoneal injection, can improve the rat central excitability. Oral the drug of chlorogenic acid and coffee acid can increase the amount of hydrochloric acid secretion in the stomach, and can make slow pulse, and quinic acid is not. Chlorogenic acid could significantly increase small intestine peristalsis on the rat or mouse. Chlorogenic acid, caffeic acid and quinic acid can increase the tension of rat uterus, this function can be cancelled by papaverine, while atropine can't influence. Caffeic acid, chlorogenic acid, also can promote bile secretion in rats. On the specimens of rabbit ileum in vitro, this product can enhance the effect of adrenaline, but has no effect on blood glucose of adrenaline.
|Protecting liver, gallbladder||Chlorogenic acid in flos lonicerae has favorable gallbladder function, promoting biliary Secretion of rats. Injection of 200 mg/kg chlorogenic acid to browns MAO honeysuckle total saponins subcutaneous can be significantly against CCl4, paracetamol and the increase of serum GPT caused by galactosamine in mice liver and liver triglyceride levels, and significantly reduce the severity of the liver pathological damage, making dot necrosis number sum and necrosis occur rate liver decreased obviously.|
|The inhibitory effect on hyaluronidase and glucose - 6 - phosphatase||Hyaluronic cranberry (HAase) is one of the cracking mucopolysaccharide enzymes, can catalyze hyaluronic acid (HA) decomposition,which is in relation to the permeability of vascular system and inflammation. HA is a mucopolysaccharide, which is composed of uronic acid and acetyl glucosamine, having a variety of functions, such as heal, make the skin wetting health, lubricating joints and prevent inflammation, etc. 3, 5-2 coffee acyl quinic acid (artichoke acid) and chlorogenic acid found in the ethyl acetate extract from the narrow assists cone flower (Echinacea amgustifolia DC) roots have stronger inhibitory effect of HAase activated. Animal in vitro studies have demonstrated that chlorogenic acid can not reversible inhibition of glucose-6-hydrolysis of phosphatase, reduce liver glycogen decomposition and exogenous glucose absorption. Animal studies have shown that the use of chlorogenic acid can reduce high blood sugar spikes caused by the use of glucagon (glycogenolysis). Therefore, chlorogenic acid can lower blood sugar level, improve the liver glucose-6-phosphoric acid and the concentration of hepatic glycogen.|
|The character of molecular structure||Chlorogenic acid is formed by caffeic acid and quinic acid, and the molecular structure has ester bond, unsaturated double bond and polyphenol unstable part of the three. In the process of extracted from plants, chlorogenic acid often happen by hydrolysis and intramolecular ester base migration isomerization . Due to the special structure of chlorogenic acid, it can extract from plants by the polarity solvent such as ethanol, acetone, methanol. But due to the instability of chlorogenic acid itself, extraction can not be in high temperature, strong light and heat for a long time. Chlorogenic acid liquid were placed in brown bottle, refrigerator (2 ºC) to save to be the most stable.|
|Preparation method||It can be obtained by (1S)-1-ethoxyformyloxy-3-cis-[3,4-dihydroxy-anti-cinnamoyl oxygen radicals]-4'-anti-5'-anti-dihydroxy cyclohexane-γ-methyl formate with barium hydroxide in methanol catalytic hydrolysis, or by the segregation from green coffee beans.|
|HPLC method for determination the content||(1)Chromatographic conditions: octadecyl silane bonded silica gel as the filling agent; Acetonitrile-0.4% phosphoric acid solution (13:87) as mobile phase; Detection wavelength of 327 nm. Theoretical plate number according to the chromatographic peak of chlorogenic acid is greater than 1000. (2)the preparation of the reference substance solution: precisely weigh the right amount of chlorogenic acid reference substance, placed in brown volumetric flask, adding 50% methanol solution containing 40 μg /mL (saving below 10 ºC). (3)the preparation of sample solution: taking samples of dry powder is about 0.5 g, precision said, with a plug in the conical flask, adding 50 ml 50% methanol , 30 min ultrasonic processing , cooling, weighing, make up the weight loss reduction with 50% methanol, shake well, filtration, abandoned the early filtrate, precision measuring duration of filtrate 5 ml, 25 ml volumetric brown flask , add 50% methanol to the scale, shake well. (4)assimilate precision respectively from each 10 μL reference substance and the sample solution, injection liquid chromatograph, determination,obtained.|
|Toxicity||Chlorogenic acid is sensitive to people, can cause asthma, dermatitis, but no this reaction to the oral of chlorogenic acid. It can be active no sensitization substances by small intestinal secretions convertion to. The toxicity of chlorogenic acid is very small, LD50 is greater than 1 g/kg to young rats, intraperitoneal injection of greater than 0.25 g/kg.|
|Chemical property||Hemihydrate is needle crystal (water). When 110 ºC, it become to anhydrous compounds. Melting point: 208 ºC, [alpha] 20D-35.2 (C = 2.8). When 25 ºC, water solubility was 4%, solubility is bigger in the hot water. Soluble in ethanol and acetone, slightly soluble in ethyl acetate.|
|Uses||It has broad antibacterial effect, advantageous bravery, hemostatic, increase white blood cell and antiviral effect, the effect of the blood clotting and bleeding time is shortened. It is used in the treatment of upper respiratory tract infection, anti-inflammatory and antipyretic, cool blood heat dissipation. Used as pharmaceutical raw materials and intermediates. clearing heat and removing toxicity, cold wind heat, broad-spectrum antimicrobial properties, having obvious inhibitory effect to hemolytic streptococcus, dysentery rod gas and salmonella typhi bacteria|
|Acute toxicity||Abdominal cavity-rat LDL0:4000 mg/kg|
|Flammability hazard characteristics||Combustible; Release acrid smoke fire|
|Storage and transport properties||Low temperature warehouse, ventilated, dry|
|Fire extinguishing agent||Water, carbon dioxide, dry powder, sand|
|Chemical Properties||white to slightly yellowish-beige powder|
|Uses||antioxidant, free radical scavenger|
|Uses||A major component of green coffee the extracts of which promote weight loss in overweight and obese people. Chlorogenic Acid is an important intermediate in lignin biosynthesis. Chlorogenic Acid is an antioxidant and an inhibitor of the tumor promoting activity of phorbol ester. It has protective effect against streptozotocin-nicotinamide generated oxidative stress induced diabetes and may also pr otect against cardiovascular disease.|
|Purification Methods||Crystallise the acid from water and dry it at 110o. [Beilstein 10 H 537, 10 I 271, 10 II 378, 10 III 2408, 10 IV 2259.]|
|Chlorogenic acid Preparation Products And Raw materials|