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What is the dosing strategy for semaglutide?

When trying to lose weight with semaglutid the goal is the least amount of nausea with the most amount of weight loss. I start patients at 0.25mg or 5 units on an insuli-n syringe. Each week patients increase their dosing by 0.25mg or 5 units until they are losing 2-5# weekly. Once a patient hits a dosing where they are losing 2# weekly, I recommend staying at this dosing until weight has plateaued for two weeks. At this point, moving up by 5 units or 0.25mg would be prudent to continue the weight loss. If nausea occurs for more than 1 day at any dosing, use a slightly lower dose the following week. For example, if week 3 at 0.75mg or 15 units made you nauseous for 2 days, bump down to 13 units or 0.65mg. If nausea does occur, use ginger as much as possible to lower this nausea.

Tirzepatide works to decrease blood sugar levels by increasing insuli-n production and also lowering the amount of sugar the liver makes. It also slows the rate food passes through your body which makes you feel full longer, and this may be one of the ways it may help weight loss.

Tirzepatid is a GIP/GLP-1 receptor agonist, which means it works on the glucose-dependent insulinotropic polypeptide (GIP) receptors and the glucagon-like peptide-1 (GLP-1) receptors.

Tirzepatide can be used as a single therapy (on its own) or with other diabetes medicines, including sulfonylureas, SGLT2 inhibitors or metformin.



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