Bp/USP 250ml 10% Glucose Injection

BP/USP 250ml 10% Glucose injection

The main ingredients and chemical name of this product are: glucose

Molecular formula: C6H12O6·H2O

Molecular weight: 198.17

Properties

This product is a colorless or almost colorless clear liquid; it has a sweet taste.

Pharmacology and Toxicology

Glucose is one of the main sources of calories in the human body. Every 1 gram of glucose can produce 4 calories (16.7KJ) of heat energy, so it is used to supplement calories and treat hypoglycemia. When glucose and insulin are intravenously infused together, potassium ions are needed for glycogen synthesis, so that potassium ions enter the cells and the blood potassium concentration drops, so it is used to treat hyperkalemia. Glucose is the main substance that maintains and regulates the osmotic pressure of peritoneal dialysate.

Pharmacokinetics

Intravenous glucose directly enters the blood circulation. Glucose is completely oxidized in the body to produce CO2 and water, which are excreted from the body through the lungs and kidneys, while generating energy, which can also be converted into glycogen and fat storage. Generally, the ability of a normal human body to utilize glucose per minute is 6 mg/Kg.

Indications

1. Supplement heat and body fluids, for inadequate eating or loss of a large amount of body fluids (such as vomiting, diarrhea, etc.), starvation ketosis caused by various reasons;

2. Hypoglycemia;

3. Hyperkalemia;

4. Prepare peritoneal dialysate;

Dosage

1. Supplementary heat energy: When the patient's eating is reduced or unable to eat due to some reasons, 10% glucose injection can be given intravenously, and body fluids can be supplemented at the same time. The amount of glucose is calculated based on the required heat energy.

2. Hypoglycemia: oral administration for mild cases. In severe cases, glucose injection can be used intravenously.

3. Starvation ketosis: oral administration for mild cases. In severe cases, intravenous infusion of glucose injection is used, and 100g of glucose per day can basically control the condition.

4. Water loss: intravenous drip of 5% glucose injection for isotonic water loss.

5. Hyperkalemia: 10% injection, plus 1 unit of regular insulin infusion for every 2~4g glucose, can reduce serum potassium concentration. However, this therapy only allows extracellular potassium ions to enter the cell, and the total potassium content in the body remains unchanged. If you do not take measures to excrete potassium, there is still the possibility of hyperkalemia again.

Adverse reactions

1. Phlebitis: occurs when hypertonic glucose injection is instilled. Switching to large intravenous drip, the incidence of phlebitis decreased.

2. Extravasation of high concentration solution injection can cause local swelling and pain.

3. Reactive hypoglycemia: combined with excessive use of insulin, the original tendency to hypoglycemia and the sudden stop of total intravenous nutrition therapy are likely to occur.

4. Hyperglycemia nonketotic coma: It is more common in diabetes, stress state, high-dose glucocorticoids, uremic peritoneal dialysis patients given intraperitoneal hypertonic glucose solution and total intravenous nutrition therapy.

5. Electrolyte disorders: Hypokalemia, hyponatremia and hypophosphatemia are prone to occur when simply supplementing glucose for a long time.

6. Those with original cardiac insufficiency.

Taboo

1. Those who have not controlled diabetic ketoacidosis;

2. Non-ketotic hypertonic state of hyperglycemia.

3. Glucose galactose malabsorption (avoid oral administration).

Precautions

1. Most gastrectomy patients are prone to dumping syndrome and hypoglycemia during oral glucose tolerance test, and should be changed to intravenous glucose test;

2. Patients with periodic paralysis and hypokalemia;

3. It is easy to induce hyperglycemia in stress state or application of glucocorticoid;

4. Edema, severe heart and kidney insufficiency, ascites due to liver cirrhosis are likely to cause water retention, and the amount of fluid infusion should be controlled; especially for those with cardiac insufficiency, the drip rate should be controlled.

[Medicine for pregnant and lactating women]

Injecting too much glucose during delivery can stimulate fetal insulin secretion and cause hypoglycemia in the baby after delivery.

Children's Medication

Too fast or too much fluid can cause palpitations, arrhythmia, and even acute left heart failure.

Medication for elderly patients

Too fast or too much fluid can cause palpitations, arrhythmia, and even acute left heart failure.

Shelf life:3years
Packaging & Shipping

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