| Certification: | ISO |
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| Assay Method: | HPLC, UV |
| Application Form: | Paste |
| Application: | Food, Health Care Products, Medicine |
| State: | Powder |
| Extract Source: | Organic Curcuma Extract |
| Samples: |
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| Customization: |
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Audited Supplier Product Name: Birch Bark Extract
Botanical Source: Betula Platyphylla
Part Used: Bark(100% Natural)
Specification: Betulinic Acid 50% -98%, Betulin 70%-98%
Appearance: Gray white to white fine powder
Description
Birch bark is an effective remedy against malaria and pneumonia. It is an excellent remedy to heal wounds, to get a low pressure up, and to relieve headaches.
In line with traditional medicine, the official medicine abroad and in Russia recognizes that birch bark and its components contain healing qualities. It is well known that birch bark is rich in betulin (birch camphor), approximately one third of the dry weight of the bark. Birch tree was dubbed "White Gold in the Boreal Forest" because of its beneficial biological effect.
The anti-stress action of birch bark has also been studied. It has been shown that betulin acts as a relieving agent for acute stomach problems such as reserpine and histamine ulcers, sub-chronic ulcers related to Butadion, as well as ulcers related to the intake of acetylsalicylic acid and acetone.
Birch bark has powerful anti-fungal, antiviral, and anti-bacterial qualities. The next time you happen to go to the forest, you should kick in a fallen birch tree with your foot: the inside of the tree will collapse, but the bark will stay intact. Russian town Novgorod birch bark letters had been lying buried in the ground for almost 700 years. They are now on exhibit in the museum in a very well preserved state.
Main Function
1.Anti- Stress
2.Birch Bark Extract has an antispasmodic, analgesic, and flogistic effect
3.Anti-fungal, antiviral, and anti-bacterial
4.Reduce fever, relieve a headache
5.Anti-HIV
6. Inhibiting the dissolution of protein in hair fiber, improving damaged hair and promoting hair growth
7.Effecting against some melanomas or cancer;
Application Filed
1,Pharmaceuticals;
2,Cosmetics;
3,Food
| Betulin Basic information |
| Extract Physical and Chemical Properties Extraction method Identification method Physiological functions Storage References |
| Product Name: | Betulin |
| Synonyms: | Betuline;BETULIN(P);betula camphor;Lup-20(29)-ene-3,28-diol, (3β)-;BETULIN hplc;BETULIN WITH HPLC;Betulin(98%);Betulin,Betulinol,Betulol,Betulenol |
| CAS: | 473-98-3 |
| MF: | C30H50O2 |
| MW: | 442.72 |
| EINECS: | 207-475-5 |
| Product Categories: | Pentacyclic Triterpenes;Tri-Terpenoids;natural product;Triterpenoids;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract |
| Mol File: | 473-98-3.mol |
| Betulin Chemical Properties |
| Melting point | 256-257 °C(lit.) |
| alpha | D15 +20° (c = 2 in pyridine) |
| Boiling point | 493.26°C (rough estimate) |
| density | 0.9882 (rough estimate) |
| refractive index | 1.5045 (estimate) |
| storage temp. | 2-8°C |
| form | Off-white powder |
| pka | 15.10±0.10(Predicted) |
| Merck | 14,1189 |
| InChIKey | FVWJYYTZTCVBKE-ROUWMTJPSA-N |
| CAS DataBase Reference | 473-98-3(CAS DataBase Reference) |
| NIST Chemistry Reference | Betulin(473-98-3) |
| Safety Information |
| Hazard Codes | Xn,Xi |
| Risk Statements | 36/37/38-20/21/22-68/20/21/22-68 |
| Safety Statements | 36/37-36-26 |
| WGK Germany | 3 |
| RTECS | OK5755000 |
| HS Code | 29181985 |
| MSDS Information |
| Provider | Language |
|---|---|
| Betulin | English |
| SigmaAldrich | English |
| Betulin Usage And Synthesis |
| Extract | Betulin is an extract from bark of the white birch tree, which has been known since the 18th century and is chemically defined. Betulin was discovered by German-Russian chemist Johann Tobias Lowitz. He was the first scientist to study and characterise betulin, and in doing was one of the first to isolate an active plant ingredient. Betulin is a substance of pure plant origin that gives the birch bark its typical white colour. Betulin protects birch trees from environmental effects, such as extreme temperatures, pest infestations and solar radiation. |
| Physical and Chemical Properties | It is white crystalline powder, soluble in alcohol, chloroform and benzene, slightly soluble in cold water, petroleum ether. |
| Extraction method | Currently Betulin is obtained mainly through direct extraction, and mainly by solvent reflux extraction and recrystallization purification Specifically: 1. Extract betulin from ethanol solution. After heating reflux about 5h, the extract is vacuum distillated and recrystallized with ethanol for 2 to 3 times with ethanol to obtain crude product of betulin. 2. The crude product was recrystallized from methanol/chloroform (1: 1) (every 80g crude product requires 300mL methanol/chloroform solution).The mixture is allowed to stand overnight and then suction filtered to obtain white needle-like betulin. 3. Ultrasonic treatment for 20min when refluxing is carried out, and the extraction yield and product purity of betulin can be improved through the destruction of bark organization. 4. The optimum conditions of supercritical CO2 fluid extraction are as follows: the amount of modifier was 115mL/(g birch bark powder); extraction pressure is 20MPa; extraction temperature was 55 ºC; liquid CO2 flow rate was 10kg/h. |
| Identification method | HPLC conditions for betulin: Isolated Constituent: Betulin(10μl sample injection) Column Stationary Phase: C18(150×2)mm 5μ Column Mobile phase: Acetonitrile/water =30:70 Flow rate (ml/min);0.2Detection Wavelength (nm):270 Column Temperature:30ºC |
| Physiological functions |
|
| Storage | Cool and dry, kept from light and temperature. |
| References | http://www.imlan.de/en/infothek/what-is-betulin.html |
| Chemical Properties | crystals |
| Uses | antineoplastic, antihyperlipidemia |
| Uses | birch bark extract is described as having anti-irritant and antiseptic properties, and effective in acne treatment. It is used to make sunburn products, soothing lotions, and aftershaves. The oil is astringent and is mainly used for its curative effects, especially in cases of acne and eczema. In folkloric medicine, birch bark extract was considered good for bathing skin eruptions. Destructive distillation of the bark's white epidermis yields an empyreumatic oil known as oil of birch tar, Oleum rusci, or dagget. This is a thick, bituminous, brownish-black liquid with a pungent, balsamic odor. It contains a high percentage of methylsalicilate, creosol, and guaiacol and is almost identical to wintergreen oil. |
| Definition | ChEBI: A pentacyclic triterpenoid that is lupane having a double bond at position 20(29) as well as 3beta-hydroxy and 28-hydroxymethyl substituents. |
| Anticancer Research | In addition, triterpenoids (betulin and its derivatives) isolated from HSSEactivated the signaling pathway regulated by p53 family genes, leading to the inhibition of BC cell viability or even the induction of apoptosis. And also, theseresearchers found that all the triterpenoids had no effect on normal breast cells.These findings provide an important basis for the use of those triterpenoids in thedevelopment of alternative therapies for breast cancer treatment (Hsu et al. 2015). |
| Betulinic acid Basic information |
| Product Name: | Betulinic acid |
| Synonyms: | 3-B-HYDROXY-LUPA-20(30)-ENE 28-OIC ACID;BETULINIC ACID;BETULIC ACID;MAIRIN;LUP-20(29)-EN-28-OIC ACID, 3-HYDROXY-, (3B)-;Lup-20(29)-en-28-oic acid, 3-hydroxy-, (3beta)-;BETULINIC ACID, TECH., 90%;BETULICACID: LUP-20(29)-EN-28-OICACID, 3-HYDROXY-, (3B)-, |
| CAS: | 472-15-1 |
| MF: | C30H48O3 |
| MW: | 456.7 |
| EINECS: | 207-448-8 |
| Product Categories: | Pentacyclic Triterpenes;Tri-Terpenoids;sy;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Antineoplastic;natural product;Inhibitors;Triterpenoids |
| Mol File: | 472-15-1.mol |
| Betulinic acid Chemical Properties |
| Melting point | 295-298 °C (dec.)(lit.) |
| alpha | D25 +7.5° (c = 0.37 in pyridine) |
| Boiling point | 550.0±33.0 °C(Predicted) |
| density | 1.065±0.06 g/cm3(Predicted) |
| refractive index | 7.8 ° (C=0.9, Pyridine) |
| storage temp. | Store at +4°C |
| form | neat |
| pka | 4.61±0.70(Predicted) |
| optical activity | [α]20/D +7.8°, c = 0.9 in pyridine |
| Merck | 14,1190 |
| InChIKey | QGJZLNKBHJESQX-FZFNOLFKSA-N |
| CAS DataBase Reference | 472-15-1(CAS DataBase Reference) |
| Safety Information |
| Hazard Codes | Xi |
| Safety Statements | 24/25 |
| WGK Germany | 3 |
| HS Code | 29181985 |
| MSDS Information |
| Provider | Language |
|---|---|
| SigmaAldrich | English |
| Betulinic acid Usage And Synthesis |
| Chemical Properties | colorless Needles |
| Uses | antineoplastic |
| Uses | Betulinic Acid is a natural pentacyclic triterpenoid. Betulinic Acid displays anti-inflammatory and anti-HIV activity. Betulinic Acid selectively induces apoptosis in tumor cells by directly activati ng the mitochondrial pathway of apoptosis through a p53- and CD95-independent mechanism. Betulinic Acid also exhibits TGR5 agonist activity |
| Definition | ChEBI: A pentacyclic triterpenoid that is lupane having a double bond at position 20(29) as well as 3beta-hydroxy and 28-carboxy substituents. It is found in the bark and other plant parts of several species of plants including Syzygium cla iflorum. It exhibits anti-HIV, antimalarial, antineoplastic and anti-inflammatory properties. |
| Biological Activity | Natural triterpenoid that displays anti-HIV and antitumor activity. Induces the production of reactive oxygen species (ROS) and activates NF- κ B. Exhibits TRG5 agonist activity (EC 50 = 1.04 μ M). |
| Anticancer Research | This compound is a pentacyclic triterpene obtained from Betula and Zizyphus species,which shows selective cytotoxicity against human melanoma cells (Shoeb2006). It generates reactive oxygen species, activates MAPK cascade, inhibitstopoisomerase I, inhibits angiogenesis, modulates pro-growth transcriptionalactivators, modulates the activity of aminopeptidase-N, and thereby inducesapoptosis in cancer cells (Desai et al. 2008; Fulda 2008). |
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