Product Profile
Eucommia ulmoides extract is extracted from the dried bark and leaves of the Eucommiaceae plant Eucommia ulmoides Oliv. The active ingredients mainly include lignans, cyclopenoid mushrooms, phenylpropanoids and other mushroom compounds, as well as polysaccharides, Flavonoids, phenols, etc. Chlorogenic acid is a phenylpropanoid compound produced by plants through the shikimic acid pathway during aerobic respiration. Chlorogenic acid is an important bioactive substance that has antibacterial, antiviral, leukocyte-increasing, liver-protective and choleretic effects, anti-tumor, lowering blood pressure, lowering blood lipids, scavenging free radicals and stimulating the central nervous system. It is widely used in pharmaceutical, daily chemical and food industries.
Function
1. Antioxidant, scavenging free radicals in the body
Chlorogenic acid and its derivatives have stronger free radical scavenging effects than ascorbic acid, caffeic acid and tocopherol (vitamin E). They can effectively scavenge DPPH free radicals, hydroxyl free radicals and superoxide anion free radicals, and can also inhibit low-density Oxidation of lipoproteins. Chlorogenic acid plays an important role in effectively removing free radicals in the body, maintaining the normal structure and function of body cells, and preventing and delaying the occurrence of tumor mutations and aging.
2. Antibacterial and antiviral effects
Chlorogenic acid and isochlorogenic acid have significant inhibitory and killing effects on a variety of pathogenic bacteria, such as Staphylococcus aureus, hemolytic Streptococcus, Shigella dysenteriae, Salmonella typhi, Pneumococcus, etc., and their antibacterial mechanism is similar to non-competitive It is related to the sexual inhibition of arylamine acetyltransferase (NAT) in bacteria. Chlorogenic acid has obvious effects on acute throat inflammation and skin diseases, and is clinically used to treat acute bacterial infections. There are reports in the literature that chlorogenic acid has antiviral, hemostatic, increased white blood cell count, and shortened blood coagulation and bleeding time.
3. Anti-mutation and anti-tumor effects
Chlorogenic acid has a strong ability to inhibit mutations, can inhibit mutations caused by aflatoxin B and mutations caused by subdigestive reactions, and can effectively reduce bone marrow red blood cell mutations caused by gamma rays; chlorogenic acid can reduce carcinogens by The utilization rate and its transportation in the liver can achieve the effects of cancer prevention and anti-cancer. Chlorogenic acid has a significant inhibitory effect on colorectal cancer, liver cancer and laryngeal cancer, and is considered an effective chemoprotective agent against cancer.
4. Cardiovascular protective effect
Chlorogenic acid, as a free radical scavenger and antioxidant, has been proven by a large number of experiments. This biological activity of chlorogenic acid can have a protective effect on the cardiovascular system. Chlorogenic acid can protect vascular endothelial cells by scavenging free radicals and resisting lipid peroxidation, thereby playing a role in preventing and treating atherosclerosis, thromboembolic diseases, and hypertension.
5. Cholesterol lowering effect
After the alcohol extract of Eucommia ulmoides was administered to rats, the total serum cholesterol was significantly lower than that of the control group, proving that Eucommia ulmoides has the effect of inhibiting cholesterol absorption.
6. Osteocyte proliferation
The water extract of Eucommia ulmoides and different extracts of the water extract were co-cultured with UMR106 osteoblast-like cells in vitro. The results showed that the water extract had the strongest effect on promoting cell proliferation when cultured at 0.4 g/L for 48 hours. Its ethyl acetate The extract and n-butanol extract have a certain promoting effect on cell proliferation, while the remaining water layer after extraction still retains a similar effect on promoting cell proliferation as the original water layer.
7.Immune regulation
Eucommia leaf extract preparation can increase the spleen weight, spleen tissue RNA and protein synthesis in mice injured by cyclophosphamide, increase the activity of natural killer cells in the blood, and accelerate the proliferation of spleen lymphocytes, but has no significant effect on spleen antibody-forming cells in normal mice.
8. Sex hormones and gonadotropin-like effects
Eucommia ulmoides extract can increase the weight of animal prostate, ovaries, testicles, levator ani muscles, etc.
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