Transport Package: | 20bou/Drum |
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Specification: | 99% |
Trademark: | NCPC |
Origin: | China |
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Customization: |
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Product Name: Procaine Benzylpenicillin or Penicillin G Procaine
Synonyms: Procaine Benzylpenicillin, Penicillin G Procaine, Benzylpenicillin procaine, Procaine Penicillin G, Novocaine Benzylpenicillin, Penicillin G Novocaine
CAS Number: 54-35-3
Characteristics: White or almost white crystalline powder
Assay: 96.0% ~ 102.0% Procaine Benzylpenicillin, Penicillin G Procaine
Formula: C29H38N4O6S
Structure Formula:
Package information: 20BOU/Drum
KEY Words: Procaine Benzylpenicillin, Penicillin G Procaine, Procaine Penicillin G, Benzylpenicillin Procaine, Penicillin G Novocaine API Raw Material Powder
Chemical Name: 2-diethylaminoethyl 4-aminobenzoate (6R)-(2-phenylacetamido) penicillinate monohydrate
Description:
Procaine Benzylpenicillin or Penicillin G Procainea combination of Penicillin G and Procaine.
Penicillin G is an antibiotic. That is why Penicillin G is noted to posses effectiveness mainly against gram-positive organisms. Some gram-negative organisms such as Neiserria gonorrhoeae and Neiserria meningitidis are also reported to be susceptible to penicillin G.
Penicillin G is also known as benzylpenicillin. Procaine is also known as Novacaine.
Benzylpenicillin contains a 6′ phenylacetyl side chain. In acid aqueous solutions, penicillin is reported to decompose into penillic acid and penilloic acid.
Procaine or Novocaine is a noted sodium channel blocker with a variety of inhibitory effects.
In skeletal muscle, procaine (Novocaine) has been reported to inhibit calcium-induced calcium release. Procaine is also noted to act as a DNA methylation inhibitor and it will cause demethylation and reactivation of methylation-silenced genes.
Procaine or novocaine is reported to induce neuronal apoptosis in a manner correlated with lipid solubility of the compound.
Procaine benzylpenicillin , also known as Procaine Penicillin G, is an antibiotic useful for the treatment of a number of bacterial infections. It is a form of penicillin which is a combination of benzylpenicillin and the local anaesthetic agent procaine. Following deep intramuscular injection, it is slowly absorbed into the circulation and hydrolysed to benzylpenicillin -- thus it is used where prolonged low concentrations of benzylpenicillin are required. This combination is aimed at reducing the pain and discomfort associated with a large intramuscular injection of penicillin. It is widely used in veterinary settings.
Usage:
Procaine Benzylpenicillin also know as Penicillin G Procaine, Procaine Penicillin G, Benzylpenicillin Procaine, Penicillin G Novocaine. It has both the function of Procaine and Penicillin. They work together.
Procaine Benzylpenicillin is a widely used substance in pharmaceutical area.
As a professional China Penicillin G Procaine, Procaine Penicillin G Raw Material supplier and Manufacturer in China, FENGCHEN GROUP CO., LTD has been supplying and exporting Procaine Benzylpenicillin, Benzylpenicillin Procaine, Penicillin G Novocaine API from China in China for almost 10 years.
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Procaine benzylpenicillin also known as penicillin G procaine, Penicillin G Procaine, Procaine Penicillin G, Benzylpenicillin Procaine, Penicillin G Novocaine, is an antibiotic which will help the treatment of a lot of bacterial infections. Specifically, Procaine Benzylpenicillin, Penicillin G Procaine, Procaine Penicillin G API Raw Material Powder is widely indicated for syphilis, anthrax, mouth infections, pneumonia, diphtheria, cellulitis, and animal bites. Benzylpenicillin Procaine, Penicillin G Novocaine is given by injection into a muscle.
However, there can be Side effects include pain at the site of injection, blood clotting problems, seizures, and allergic reactions including anaphylaxis, etc. Procaine Benzylpenicillin, Penicillin G Procaine, Procaine Penicillin G is also popularly utilized to treat syphilis. It is not recommended for the people who have a history of penicillin allergy or procaine allergy. Usage of Benzylpenicillin Procaine, Penicillin G Novocaine during pregnancy and breastfeeding is relatively safe. Procaine benzylpenicillin is in the penicillin and beta lactam family of medications. Procaine Benzylpenicillin, Penicillin G Procaine, Procaine Penicillin G acts via benzylpenicillin and will kill the bacterial. Procaine makes the combination long acting.[3]
In the year 1948, Benzylpenicillin Procaine, Penicillin G Novocaine was firstly introduced for pharmaceutical use. It is the most effective and safe medicines needed in a health system.
Medical uses:
Specific indications for Procaine Benzylpenicillin, Penicillin G Procaine, Procaine Penicillin G are as following:
-Syphilis
In the United States, Bicillin C-R (a injectable suspension which 1.2 million units of benzathine penicillin and 1.2 million units of procaine penicillin per 4 ml) is not recommended for treating syphilis, because it contains only 50% the suggested dose of Benzylpenicillin Procaine, Penicillin G Novocaine. Medication errors have been made due to the confusion between Bicillin L-A & Bicillin C-R. As a result, changes in product packaging have been made; specifically, the statement "Not for the Treatment of Syphilis" has been added in red text to both the Bicillin CR and Billin CR 900/300 syringe labels.
-Together with Erythromycin, Procaine Benzylpenicillin, Penicillin G Procaine, Procaine Penicillin G is used to treat strep throat, given as one IM injection
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Benzylpenicillin Procaine, Penicillin G Novocaine is also used as an adjunct in the treatment of anthrax.
Adverse effects of Benzylpenicillin Procaine, Penicillin G Novocaine:
At high doses, procaine penicillin might cause seizures and CNS abnormalities due to the procaine present in it.
Mechanism of action of Procaine Benzylpenicillin, Penicillin G Procaine, Procaine Penicillin G:
This product is a form of penicillin which is a combination of benzylpenicillin and the local anaesthetic agent procaine. Following deep intramuscular injection, Benzylpenicillin Procaine, Penicillin G Novocaine will be absorbed into the circulation slowly and hydrolysed to benzylpenicillin. Therefore, Procaine Benzylpenicillin, Penicillin G Procaine, Procaine Penicillin G is used where prolonged low concentrations of benzylpenicillin are needed in the treatment.
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Main indexes of Penicillin G Novocaine (Penicillin G Procaine)
Testing Item |
Standard |
Result |
Appearance |
White or almost white crystalline powder |
Complies |
Identification |
IR spectrum complies with that of reference standard (IR) |
Complies |
pH (50mg/15ml H2O) |
5.0 ~ 7.5 |
5.9 |
Specific Optical Rotation |
+165° ~ +180° |
+172° |
Moisture |
2.8% ~ 4.2% |
3.1% |
Related Substances |
Impurity A: Not more than the area of the corresponding peak in the chromatogram obtained with reference solution(c) ≤ 0.024% |
4-aminobenzoic acid: |
Any other impurity (B, C, D, E): for each impurity not more than the area of the peak due to benzylpenicillin in the chromatogram obtained with the reference solution(c) ≤ 1% |
Not detected |
|
Residual Solvents(GC) |
n-Butanol ≤ 5000ppm |
89ppm |
Ethyl acetate ≤ 5000ppm |
8ppm |
|
Bacterial Endotoxins |
< 0.10IU/mg |
< 0.10IU/mg |
Procaine (HPLC) |
39.0% ~ 42.0% |
40.9% |
Procaine Benzylpenicilln |
96.0% ~ 102.0% |
99.4% |
Sterility |
Should comply |
Complies |
This product complies with both BP and EP standard.
Top Quality, China Pure Procaine Benzylpenicillin, Penicillin G Procaine, Procaine Penicillin G, Benzylpenicillin Procaine Powder/Substance factory in China; China Procaine Benzylpenicillin, Penicillin G Procaine, Procaine Penicillin G, Benzylpenicillin Procaine Raw Material Suppliers in China. China Procaine Benzylpenicillin, Penicillin G Procaine, Procaine Penicillin G, Benzylpenicillin Procaine API Manufacturers in China.
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ITB Biopharm Co., Ltd is a comprehensive enterprise which integrates R & D, production and construction of pharmaceutical production equipments, development and transfer of biotechnology, and cooperative production and sales of drugs and vaccines. The self-developed pharmaceutical production equipment branded ITB has been put into operation in many well-known pharmaceutical enterprises such as NCPC&CSPC and also cooperates with many well-known pharmaceutical enterprises in production and sales, including pharmaceutical intermediates, APIs and finished drug preparations.
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