Dutasteride is a new dual inhibitor of 5α reductase that inhibits both 5α reductase-1 and 5α reductase-2. It is more effective than finasteride in reducing DHT concentrations (94.7% vs. 70.8%). Dutasteride inhibited 5α reductase-1 60 times more than finasteride. The incidence of prostate cancer was 50% lower in the dutasteride group than in the placebo group 27 months after dutasteride administration.
Dutasteride CAS 164656-23-9 of Chemical PropertiesMelting point 88-92 °C(lit.)Melting point 242-250°C
Boiling point 620.3±55.0 °C(Predicted)
density 1.303±0.06 g/cm3(Predicted)
storage temp. -20°C
solubility DMSO: soluble2mg/mL, clear
pka 13.32±0.70(Predicted)
form powder
color white to beige
optical activity [α]/D +18 to +24°, c = 1 in chloroform-d
InChIKey JWJOTENAMICLJG-QWBYCMEYSA-N
Function and Application of Dutasteride CAS 164656-23-9
1. Used in the treatment of benign prostatic hyperplasia. Dual inhibitor of 5a-reductase isoenzymes type 1 and 2; structurally related to Finasteride.
2. Used in the treatment of benign prostatic hyperplasia. Dual inhibitor of 5α-reductase isoenzymes type 1 and 2; structurally related to Finasteride.
3. Dutasteride is a dual inhibitor of 5α-reductase isoenzymes type 1 and 2; structurally related to Finasteride (F342000). Dutasteride is used in the treatment of benign prostatic hyperplasia.
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