To know their differences,firstly you need to know why do so many medications appears as a salt form. A considerable proportion of drugs are organic acid or alkali salt, and often is a weak organic acid and strong inorganic base, weak organic base and strong inorganic acid salt. As a result of salt, so that some oil loaded organic acids or a few bases into a solid, is conducive to the preparation of some solid dosage forms; The salinization of drugs increases water solubility, which is beneficial to the preparation of some water-containing dosage forms, such as water injection and oral liquid. Into salt process, often also is a kind of purification process to remove the mixed cannot into salt impurities in the drug, but sometimes also can bring some problems worthy of note, for example, in the process of salt crystallization can adsorption and bag miscellaneous go into salt organic impurities (such as the reaction steps of raw materials or by-products), even if in the later recrystallization process is also difficult to completely remove them. At this point, it is necessary to pretreat the free organic acid or organic base of the drug before salt formation, and remove the impurities before salt formation.
A simple understanding is ,a salt form will make the substance more steady and with high water solubility and absorbency.Back to our origin objects:Tianeptine Sodium Salt Vs Tianeptine Acid Vs Tianpetine Sulfate.Now you may understand why there are three forms of Tianpetine.
Tianeptine it is very hygroscopic. This makes handling and storage a pain. More importantly, its short half life and pharmacodynamic properties make dosing required up to 3 times a day. This is where a more controlled release form comes into play.The salt form has improved the stability,the free acid form is the next outcome from Tianeptine sodium salt.
Tianeptine hemisulfate monohydrate is an improved salt of Tianeptine. It is not hygroscopic so handling the powder is a lot easier. Since it is not as readily absorbed and excreted from the body, the sulfate salt allows for a more controlled release of the
Tianeptine over longer periods. Rather than having to dose three times with rapid peak effects and rapidly falling effects, the sulfate salt allows for one dose to maintain plasma levels in the body much longer than the sodium salt. These improved characteristics make Tianeptine Sulfate a novel addition.
As for the half-life of the three forms, Sodium is the shortest lasting, then comes free acid, and then sulfate. Free acid and sulfate are better suited for a taper because of their slow ramp up and slow ramp down, in addition to lasting quite a bit longer than sodium. Free acid and sulfate really shine at night by letting you sleep through the whole night without waking up in WD's and having to dose. With free acid and sulfate, you won't get a high per-se, but rather a smooth and subtle mood boost. I learned to prefer it over the sodium high.