| CAS No.: | 50-65-7 |
|---|---|
| Formula: | C13H8Cl2N2O4 |
| EINECS: | 200-056-8 |
| Appearance: | Powder |
| Source: | Organic Synthesis |
| Toxicity of High and Low: | Low Toxicity of Reagents |
| Samples: |
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| Customization: |
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Introduction
Product Name: Niclosamide
CAS NO.: 50-65-7
EINECS NO.: 200-056-8
MF: C13H8Cl2N2O4
MW: 327.12
Melting point: 225-230ºC
Appearance: light yellow powder
Mechanism of action: According to an article in Nature, niclosamide uncouples oxidative phosphorylation in the tapeworm.
Function
Niclosamide is not easy to absorb orally, maintains a high concentration in the intestines, kills the head and near segments of the aphids, and is clinically used to expel beef aphids, pork aphids and short-shelled aphids, which are more effective than betel nut and pumpkin seeds. It is also used as a molluscicide. It can kill snails and cercariae cercariae and edulis at a concentration of 0.2 to 0.5 parts per million. The dosage is 1 g/m2. This product is harmless to warm-blooded animals and plants, but only to fish. This product can also be used as a coating agent for application to the skin before launching to prevent acute schistosomiasis infection and rice dermatitis. (Niclosamide is included in the WHO Essential Medicines List for use when praziquantel treatment is ineffective)
Application
Niclosamide is a teniacide in the anthelmintic family especially effective against cestodes that infect humans. It is also used as a piscicide. It is stressed that while antihelmintics are a drug family used to treat worm infections, Niclosamide is used specifically to treat tapeworms and is not effective against other worms such as pinworms or roundworms. It is a chewable tablet taken orally, dosage depending on type of worm and patient's age and/or weight.Niclosamide molecules are lethal to tapeworms upon contact.
Specification
|
Items |
Specification |
Result |
|
Assay by HPLC |
≥98.0% |
98.12% |
|
Appearance |
Yellow or hazel powder |
Yellow powder |
|
Melting point |
229~231ºC |
230ºC |
|
PH Value |
6~9 |
7.2 |
|
Inorganic salt |
≤1.0% |
0.36% |
|
Water |
≤0.5% |
0.3% |
|
As,mg/kg |
≤0.3% |
0.032 |
|
Loss on drying |
≤0.5% |
0.24% |
|
Total plate count |
≤100cfu/g |
Complies |
|
Cont of bacteria |
≤100cfu/g |
<10cfu/g |
|
Yeast&Mould |
<10ppm |
Complies |
|
Coli form MPN/100g |
≤30 |
Negative |
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