Astragalus root has polysaccharides that have a role in influencing the immune system. Astragalus root also contains saponins called astragalosides and astramembranosides, along with flavonoids and triterpenes. Three major flavonoids are ononin, along with formononetin, and demethylhomopterocarpin.
Astragalus membranaceus Bge.
Part of used
Orange fine powder or slurry -yellow brown
UV 10-70%( Polysaccharides), HPLC 0.3-98% (Astragalosides)
Int J Mol Med. 2013. Astragalus polysaccharide induces anti-inflammatory effects dependent on activity in palmitate-treated RAW264.7 cells. School of Basic Medical Sciences, Wuhan University, Wuhan, P.R. China.
Sixty patients with aplastic anemia were randomly assigned to two groups equally, both were treated with three times a day, 2 mg each time through oral intake, but astagalus was given additionally to the patients in the treated group once a day via intravenous dripping. All were treated for 15 days as one therapeutic course and the whole medication lasted for more than 4 months totally, with follow-up adopted.
Astragalus polysaccharide exerts sensitizing and hypoglycemic activities in type 2 diabetic rats. The present study was designed to confirm the hypoglycemic effect of Astragalus polysaccharide and to investigate its possible mechanism underlying the improvement of resistance in vivo and in vitro. We found Astragalus polysaccharide could alleviate resistance induced by high glucose. The hyperglycemia, hypolipemia, and status were controlled with Astragalus polysaccharide therapy. action in the liver of resistant mice was restored significantly with Astragalus polysaccharide administration. The anti-obesity effect and hypolipidemia effects of Astragalus polysaccharide were probably due partly to decreasing the leptin resistance of mice, which would positively couple with the normalization of plasma levels.
Chin Med J. Protective effects of astragalus extract against intermittent hypoxia-induced hippocampal neurons impairment in rats. School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China; Tianjin Institute of Geriatrics, Tianjin Medical University General Hospital, Tianjin, China.
Alteration of immune function may be associated with chronic fatigue syndrome (CFS) and this study reveals the immunoregulatory effect of Astragalus membranaceus flavonoids. Rats were induced by food intake restriction plus forced swimming for 6 weeks. An atrophied spleen associated with a significantly decreased spleen/body weight ratio and a reduced spleen cells proliferation was found in these rats when compared with home cage controls. Astragalus membranaceus flavonoids given orally at 20, 50 and 100mg/kg body weight once a day consecutively for 6 weeks recovered the reduced cell proliferation. A switch to Th1-dominated immune regulation was observed in these rats as the cultured splenocytes produced more interleukin-2 (IL-2) but less IL-4 when compared with controls. Supplementation with Astragalus membranaceus flavonoids counteracted the aberrant cytokine production and rats receiving Astragalus membranaceus flavonoids exhibited higher endurance capacity to swim when compared with those without the herb.
Astragalus improves certain parts of the immune system, and may have some anti-HIV activity. It's not clear whether astragalus would have anti-HIV activity when ingested as a supplement.
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