n-Octyl cyanoacrylate, Ocrylate
Raw material for Tissue adhesive/surgical glue.
2-Propenoic acid,
2-cyano-, octyl ester
CAS No.:6701-17-3
EINECS: 229-748-8
Purity: 98%min
Alias:
Acrylicacid 2-cyano-octyl ester, Octyl 2-cyanoacrylate, Ocrylate, n-Octyl cyanoacrylate, Nexaband, 2-Cyanoacrylic acid octyl ester, Capryla-cyanoacrylate, n-Octyl a-cyanoacrylate, Ocrilate, Octyl cyanoacrylate, Octyl a-cyanoacrylate, n-Octyl 2-cyanoacrylate.
History and development of cyanoacrylate tissue adhesive:
In 1959, a variety of cyanoacrylate adhesives were developed, some types of which are now used for surgical purposes in Canada and Europe. These glues polymerize on contact with basic substances such as water or blood to form a strong bond. The first glue developed was methyl cyanoacrylate, which was studied extensively for its potential medical applications and was rejected due to its potential tissue toxicity such as inflammation or local foreign body reactions. Methyl alcohol has a short molecular chain which contributes to these complications.
Further research revealed that by changing the type of alcohol in the compound to one with a longer molecular chain, the tissue toxicity was much reduced. All the medical grade tissue adhesives currently available for human use contain butyl-esters, which are costlier to produce.
Histoacryl Blue (n-butyl cyanoacrylate) has been used extensively in Europe since the 1970s for a variety of surgical applications including middle ear surgery, bone and cartilage grafts, repair of cerebrospinal fluid leaks, and skin closure. It has been available in Canada through Davis & Geck Canada, with no adverse effects reported to date.
Rapid curing may also lead to tissue necrosis. Midwives have not noted such reactions because minimal amounts are being used for perineal repair. Nevertheless, with a greater toxic potential, over-the-counter products are inappropriate for use in wound closure. (Quinn & Kissick, 1994)
Medical grade products currently available contain either butyl, isobutyl or octyl esters. They are bacteriostatic and painless to apply when used as directed, produce minimal thermal reaction when applied to dry skin and break down harmlessly in tissue. They are essentially inert once dry. Butyl products are rigid when dry, but provide a strong bond. Available octyl products are more flexible when dry, but produce a weaker bond.
When used for repair, ideally the wound to be closed is fresh, clean, fairly shallow, with straight edges that lie together on their own. The glue is applied to bridge over the closed edges; it should not be used within the wound (on raw surfaces), where it will impair epithelization.
Jingzhou Shengjie Technology Co., Ltd. is located in Jiahai Zheshang Industrial Park, jingzhou City, Hubei Province. It has a production area of 3,000 square meters, and is equipped with an independent R&D laboratory of 500 square meters. We provide customers with high quality cyanoacrylate adhesives, industrial application adhesives and solutions for difficult-to-stick materials. The founder of the company, Mr. Wang, used to work in a China's largest adhesive company, responsible for production and technical work, focusing on the R&D and production of cyanoacrylate adhesive products for more than 20 years. He started Shengjie Technology in 2015, set up many highend instant adhesive brands such as StarSpeed and MIAOMIAO GU, all have very high reputations and brand values in the related industries.
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