Business Type: Manufacturer/Factory
Wuhan, Hubei, China
Hot Sale 99% 100mg 1g Prostaglandin E1 Pge 1 Alprostadil Powder CAS 745-65-3
|Product Name||Prostaglandin E1|
|Synonyms||11,15-Dihydroxy-9-oxoprost-13-en-1-oic acid; 3-Hydroxy-2-(3-hydroxy-1-octenyl)-5-oxo-cyclopentaneheptanoic acid; PGE1|
|Appearance||White or almost white powder|
|Boiling Point||529.3 °C at 760 mmHg|
|Flash Point||288 °C|
|Solubility||Insoluble in water|
Prostaglandin E1 is used to treat erectile dysfunction through its vasodilatation function and is sold under the American trade name Muse or Vivus for erectile urethral embolization. It can also be used as a brand name for Caverject and Edex, which are injectable forms. Prostaglandin E1 will be used as a penile drug delivery system to insert the urethra for at least ten minutes before you need an erection. In contrast, the same quick effect of Caverject and Edex is also directly injected into the penile corpus cavernosum.
The drug is recommended for men with erectile dysfunction. You can also use this drug to keep the patent ductus arteriosus of the newborn. This is primarily effective when ductal ductus arteriosus is not associated with ductal congenital heart disease, including areola lesions (ie, aortic arch disruption, aortic stenosis, dysplastic left ventricular syndrome and aortic coarctation). The Prostaglandin E1 is used for penile erection as needed. The effect starts at about 5 to 10 minutes after administration and lasts for about 30 minutes to 1 hour.
PGE1 is an effective drug for opening the catheter to a catheter that relies on congenital heart disease. It can be used in the first week of life than the efficacy of newborns. Apnea is the main side effect, and close monitoring is essential.
Prostaglandin E1 was packaged in 500 mg (0.5 mg) of 1 ml ampoule. Use one of the following methods to prepare the infusion solution.
Dissolve an arsenic in 500 ml D5W or D10W = 1 mcg / ml (0.001 mg / ml) solution.
Given 0.05 mcg / kg / min. = 3.0 ml / kg / hr
[Body weight (kg) ÷ 10] = # mg PGE1 in 100 ml IVF, 3 ml / hr = 0.05 mcg / kg / min
A vial was diluted in 100 ml D5W or D10W = 5 mcg / ml solution. Given 0.05 mcg / kg / min. = 0.6 ml / kg / hr
Ensure that the drug is well mixed in solution and that all piping is cleared. After mixing, the solution was stabilized for 24 hours. Prostaglandin E1 is infused through the pump through a large peripheral vein (preferably not a scalp vein) or umbilical cord blood. There is evidence that doses greater than 0.1 mcg / kg / min are not more effective and may lead to increased adverse events.
Neonates usually respond with PaO2 within 10-15 minutes after the start of the drug. Some patients may react after a few hours of drug infusion has passed. The half-life of the drug is a cycle time; therefore, continuous continuous infusion must be maintained. Once the patient reacts, the dose can be reduced to half or less of the initial effective dose.
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