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Fasoracetam (NS-105, LAM-105) was initially developed for the treatment of Alzheimers by Nippon Shinyaku.
A member of the racetam family, a class of compounds famed for their cognition enhancing properties, it also shows promise as an antidepressant and anxiolytic.
Dr. Hakonarson, who specializes in genome medicine, is exploring the drug's usefulness as an ADHD drug for a particular genetic subset of the population.
Fasoracetam works on three different types of receptors in tandem: the cholinergic, GABA and glutamate.
These receptors are all associated with the formation and retention of new memories. This has been proven in the laboratory.
What is Fasoracetam?
Fasoracetam is a powerful Racetam compound with a chemical structure of (5R)-5-(piperidine-1-carbonyl) pyrrolidin-2-one.
Primarily it has attracted the interest of nootropics enthusiastssearching for ever stronger analogues of the original racetam, Piracetam.
Fasoracetam improves general intelligence while attacking anxiety and apathy, which, as much as a lack of ability, can stand in the way of reaching one's full potential.
These are also frequent concerns for patients diagnosed with ADHD which explains the interest in researching its effects for this disorder.
Fasoracetam prevents learned helplessness. In animal trials, rats given the drug were substantially less likely to remain immobile when submersed in water than those who were not. They were also more motivated to rescue themselves from merciless electrical shocks on their feet.
While human studies have yet to be conducted in this area, it was found to increase "the number of GABAB receptors in rat cerebral cortex without affecting the binding properties of adrenoceptors and 5-HT2 receptors."
This is remarkable. This means the brain does not, as several recreational users have reported, build a tolerance to fasoracetam; each dose is as or more effective at alleviating depression and anxiety as the last. Its mechanism of action is not like Prozac's.
Nor does it affect monoamine uptake or its circulating concentration within tissues. Its short term safety has been established, but it is not certain whether it is as well tolerated long term as Piracetam or Aniracetam.
For now, the use of Fasoracetam is limited as a nootropic supplement. It is fairly hard to track down and comparatively costly.
You can buy it from several nootropic research compound suppliers, but remember that it has yet to be approved for human use in the USA and this carries some inherent risk.
Its antidepressant effects are most prominent at large doses and a standard dose has not yet been agreed upon. In human trials, 100mg a day has been given to subjects with no observed consequences, but some psychonauts use only 10mg a day sublingually.
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