| Certification: | ISO |
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| Assay Method: | HPLC, UV |
| Application Form: | Paste |
| Application: | Food, Health Care Products, Medicine |
| State: | Powder |
| Extract Source: | Maca Extract |
| Samples: |
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| Customization: |
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Audited Supplier Cranberry Extract
Product Name: Cranberry Extract
Botanical Source: Vaccinium Macrocarpon L.
Part Used: Berry Part(Dried, 100% Natural)
Specification: Anthocyanins 25% to 35%; Anthocyanidins 25% to 35%; Proanthocyanidins (OPC) 5% to 50%
Appearance: Purple red fine powder, slightly bitter taste.
Description
Cranberry is a low-growing evergreen shrub with leathery leaves and bright red berries. This member of the heath family main grows in mountains, forests and damp bogs in north-east of China,America and Canada.Cranberries are distinguished by their extremely sour taste, due to their low sugar and high acid content. Cranberries are rich in citric, malic, quinic and other acids. They also contain flavonoids, anthocyanins, ellagic acid, and vitamin C. Because of their tannin content, the berries possess a natural astringency. Recent research supports the notion that cranberries contain substances that prevent the adhesion of E coli and other bacteria to the lining of the urinary tract.
Main Function
1.Improving the Urinary System,preventing urinary tract infection;
2.Softening blood capillary;
3.Eliminating eyestrain, improving eyesight and delaying cerebral nerve to
4.aging;
5.Enhancing the heart function and resisting cancer;
6.It has curative effect on immunity diseases of blood capillary caused by
7.Diabetes.
Application Filed
1.Functional food,
2.Drinks,
3.Health care products,
4.Pharmaceuticals.
Specification
| Appearance | dark purple red powder |
| Proanthocyanidin | 10-30% |
| Sulphated Ash | <3.0% |
| Loss on drying | <3.0% |
| Total Plate Count | <1000cfu/g |
| Yeast&Mold | <100cfu/g |
| E.Coli | Negative |
| Salmonella | Negative |
| S.Aureus | Negative |
| Pesticides | Negative |
| 1-Deoxynojirimycin Basic information |
| Chemical Name Alkaloids |
| Product Name: | 1-Deoxynojirimycin |
| Synonyms: | 1-Deoxynojirimycin 19130-96-2;1,5-dideoxy-1,5-imino-d-glucito;1,5-dideoxy-1,5-imino-d-glucitol;1-deoxynojirimicin;1-deoxy-nojirimyci;5-amino-1,5-dideoxy-d-glycopyranose;5-dideoxy-5-amino-d-glucopyranos;5-piperidinetriol(2r-(2alpha,3beta,4alpha,5beta))-2-(hydroxymethyl)-4 |
| CAS: | 19130-96-2 |
| MF: | C6H13NO4 |
| MW: | 163.17 |
| EINECS: | 606-239-2 |
| Product Categories: | Miscellaneous Natural Products;All Inhibitors;Glycosidase Inhibitors;Inhibitors;Miscellaneous Enzyme;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract |
| Mol File: | 19130-96-2.mol |
| 1-Deoxynojirimycin Chemical Properties |
| Melting point | 195-196°C |
| Boiling point | 361.1±42.0 °C(Predicted) |
| density | 1.456±0.06 g/cm3(Predicted) |
| RTECS | TN4350300 |
| storage temp. | Desiccate at +4°C |
| pka | 13.77±0.70(Predicted) |
| form | Powder |
| color | White |
| Water Solubility | Soluble in water, dimethyl sulfoxide and methanol. |
| BRN | 3588039 |
| CAS DataBase Reference | 19130-96-2(CAS DataBase Reference) |
| Safety Information |
| Safety Statements | 24/25 |
| WGK Germany | 1 |
| HS Code | 29329990 |
| MSDS Information |
| Provider | Language |
|---|---|
| (2R,3R,4R,5S)-2-Hydroxymethyl-piperidine-3,4,5-triol | English |
| 1-Deoxynojirimycin Usage And Synthesis |
| Chemical Name | (2R,3R,4R,5S)-2-Hydroxymethyl-piperidine-3,4,5-triol |
| Alkaloids | 1-deoxynojirimycin is referred DNJ for short , it is an alkaloid extracted from the bark of mulberry leaves and roots, but it also exists in other plants and microorganisms. This product is an effective α-glucosidase inhibitor, it has significant hypoglycemic effect. After 1-deoxynojirimycin goes into the human body, it can inhibit sucrose, maltase, α-glucosidase enzyme, α-amylase decomposing starch, sugar in the human body , thereby it can block the body's absorption of sugar, inhibiting blood sugar rising to achieve the effect of prevention and treatment of diabetes, the use of it does not cause changes in diet . In addition, DNJ can inhibit glucose modification process of HIV tunica glycoprotein , at the same time, the accumulation of immature glycoproteins may inhibit cell fusion, viral and host cell receptor can combine,which causes syncytia formation to inhibit the replication of MoLV ,then the virus activity is inhibited. Nojirimycin is first discovered from Streptomyces, and natural DNJ is first isolated from the bark of mulberry root. In plants, from mulberry, dayflower, hyacinth and Adenophora plants, DNJ has been isolated and identified , DNJ has the highest content in the mulberry and because of mulberry varieties, medicinal parts, seasonal climate, geography, soil, leaf position, different developmental stages and other factors , there is a big difference. In a microorganism, from a variety of Streptomyces and Bacillus,DNJ is isolated ,it is also found that two kinds of endophytes separated from Mulberry including Stenotrophomonas oligotrophic Pseudomonas and Micrococcus can produce DNJ,fermentation conditions of a variety of microbial production of DNJ are studied. In insects, in addition to silkworm rich in DNJ , single or oligophagous insects with eating mulberry leaves habit including wild silkworm, mulberry geometrid, Diaphania pyloalis Walker , mulberry white capterpillar are also rich in DNJ , DNJ in insects bodies are from the food , content of DNJ in Bombyx bodies is different due to the different varieties of silkworm, developmental stages, tissues and organs as well as feed and other factors, with the silkworm age of progress ,there is the existence of cyclical changes in absorption and accumulation and excretion of DNJ. Now DNJ biosynthetic pathways in Streptomyces, Bacillus and Commelina bodies are explored and it is found that synthesis of DNJ has different mechanisms in different species . In addition, three main synthesis methods of 1-deoxynojirimycin are proven , some of the synthetic derivatives of DNJ have been used clinically. Recent studies show that the active ingredient of mulberry DNJ (l-deoxynojirimycin), only exists in mulberry leaves , by blocking the α-glucosidase enzymes to hinder sugar becoming to glucose, mulberry leaf extract can inhibit intestinal glucose absorption. This can suppress the blood sugar level and blood pressure rising , and it can have good inhibitory effect on variability of imidazopyridine, benzopyrene and other carcinogenic substances,it has anti-cancer effect, at the same time ,mulberry leaf extract can reduce cholesterol, and improve liver function and eliminate constipation and so on. |
| Chemical Properties | White Crystalline Solid |
| Uses | Deoxynojirimycin inhibits mammalian glucosidase 1. As well, it inhibits intestinal and lysosmal alpha-glucosidases, beta-glucosidase from sweet almonds, pancreatic alpha-amylase and amyloglucosidase. |
| Uses | An inhibitor of α-glucosidase I and II |
| Definition | ChEBI: An optically active form of 2-(hydroxymethyl)piperidine-3,4,5-triol having 2R,3R,4R,5S-configuration. |
| Biological Activity | Inhibitor of glucosidase I (K i = 2.1 mM) and II (K i = 7 mM). |
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