Powder: | Yes |
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Customized: | Customized |
Certification: | GMP, ISO 9001, USP, BP |
Suitable for: | Adult |
State: | Solid |
Purity: | >99% |
Samples: |
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Customization: |
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Product name: Synephrine |
Other Name:D-(-)-Synephrine |
Appearance:White powder |
CAS:94-07-5 |
M.F.:C9H13NO2 |
M.W.:167.21 |
Specification:99% |
Synephrine(Sheen Flynn)is rutaceae plants of the genus citrus immature bitter orange, orange, tangerine peel, green husk and other Chinese medicinal materials of a kind of alkaloid, is the Chinese traditional medicine plays one of the main pharmacological action of active ingredients, improve metabolism, increase fat oxidation and raise the level of energy and heat consumption, the effect of weight loss, is the traditional Chinese medicine plays an important role of frutus aurantii immaturus active ingredients, increased blood volume and improve the total peripheral vascular resistance and make the left ventricular pressure and the effect of arterial blood pressure to rise,Clinically, it is mainly used for the treatment of bronchial asthma and hypotension, collapse and shock, postural hypotension, food accumulation and gastroptosis, etc. In addition to the traditional application of Traditional Chinese medicine, it is also used in the clinical application of injections for the rescue of various shock, heart failure and the treatment of gastric and duodenal ulcer and other diseases.
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ITEM | SPECIFICATION | RESULT | METHOD |
Appearance | White powder, neutral odor, highly hygroscopic | Conforms | Visual |
Identification | Standard solution and test solution same spot,RF | Conforms | TLC |
Specific Optical | -2.4°~ -2.8° | -2.72° | |
Heavy metals (as PB) | ≤10ppm | Conforms | AAS |
Sulfate (SO4) | ≤0.02% | Conforms | Colorimetry |
Chloride (Cl) | ≤0.02% | Conforms | Colorimetry |
Phosphate Ion (P) | ≤5ppm | Conforms | Colorimetry |
Residual solvent(ethanol) | ≤1.0% | Conforms | HS-GC |
pH | 4.5~7.0 | 5.10 | |
Related substance | Spot not bigger than standard solution spot | No spot | TLC |
Water Content | ≤2% | 0.26% | KF |
Assay (dried basis) | 98.0%--102.0% | 99.48% | Potentiometric titration |
Assay (dried basis) | 98.5%--100% | 99.2% | HPLC |
Function:
1. The effects on cardiovascular acid-insoluble ash and hovenia dulcis decoction, immature bitter orange extract, injection and its active ingredients of frutus aurantii immaturus Flynn intravenous, can significantly enhance the anesthetic dogs of myocardial contractility and pump function index, with a strong heart, shrink blood vessels, improve the total peripheral resistance, and make the left ventricular pressure, and the effect of arterial blood pressure to rise.Modern studies have also confirmed that FAI can increase the aortic tension and make the aortic smooth muscle contract in a concentration-dependent manner.
2.As a weight loss stimulant, synephrine ACTS by stimulating -3 adrenergic receptors leading to lipid breakdown and subsequent thermogenesis.Most dietary supplements that contain synephrine also contain different ingredients, mainly caffein, salicylic acid and ephedrin.The combination of these chemicals can improve the weight loss effect of Synephrine.
3.Effects on blood pressure In pharmacology, synephrine is used as a decongestant to treat hypotension by oral administration.It has also been reported that Synephrine has significant pressure boosting effects, such as strengthening myocardial contractility, slowing heart rate, increasing cardiac output, increasing coronary flow, and increasing renal blood flow.
4. Effect on diabetes: Immaturi frutesi extract simferin can enhance the antioxidant capacity of liver and reduce the damage of liver cells.
5.Effects of p-synephrine on depression P-synephrine has an obvious antidepressant effect on behavioral despair in animal models of depression, which can counteract the despondent behavior and reduce the despondent behavior (immobilization time), which may be related to the stimulation of alpha-1 adrenergic receptors.May have therapeutic effects on antidepressant effects in patients with hypotension.
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