Glucose Injection 5% 500ml Intravenous Infusion with GMP

GLUCOSE INJECTION 5%,500ML

Indications:

5% Glucose Intravenous Infusion Solution is indicated for:

• fluid replacement, administered alone or in regimens with electrolytes or additives known to be compatible with 5% glucose.

• medium for intravenous administration of medicinal products known to be compatible with 5% glucose.

Dosage and Administration:

Fluid balance, serum glucose, serum sodium and other electrolytes may need to be monitored before and during administration, especially in patients with increased non-osmotic vasopressin release (syndrome of inappropriate antidiuretic hormone secretion, SIADH) and in patients comedicated with vasopressin agonist drugs due to the risk of hyponatraemia.

Monitoring of serum sodium is particularly important for physiologically hypotonic fluids. 5% Glucose Intravenous Infusion Solution may become extremely hypotonic after administration due to glucose metabolization in the body.

To avoid dehydration in a healthy adult or in patients with no complicating factors such as fever or excessive fluid losses, daily fluid requirements are 1.5 to 2.5 litres. The volume of glucose solution needed to replenish deficits will vary with body weight, complementary treatment, severity of the clinical condition and hydration status of the patient, but in adults will usually lie between 2 and 10 litres. The pathophysiological response to dehydration, to electrolyte loss and to glucose infusion will vary with the age of the patient being treated and this should be taken into account during rehydration therapy. There is no recommended dose as this is a matter for clinical judgment and laboratory assessment in each case. The dose range is typically 500 - 3000ml in a 24 hour period and typical maximum rates are 800mg/kg/hr or 600ml/hr.

For intravenous infusion under medical supervision.

Precautions & Warning:

Glucose infusions are incompatible with blood for transfusion as haemolysis or clumping can occur; do not administer through the same infusion equipment as blood or blood components for transfusion (either before, during or after their administration).

Contra-indications:

Hyperglycaemia. Conditions of water excess

Drug interactions:

Drugs leading to an increased vasopressin effect

• Drugs stimulating vasopressin release, e.g.:

Chlorpropamide, clofibrate, carbamazepine, vincristine, selective serotonin reuptake inhibitors, 3.4-methylenedioxy-N-methamphetamine, ifosfamide, antipsychotics, narcotics

• Drugs potentiating vasopressin action, e.g.:

Chlorpropamide, NSAIDs, cyclophosphamide

• Vasopressin analogues, e.g:

Desmopressin, oxytocin, vasopressin, terlipressin

Other medicinal products increasing the risk of hyponatraemia also include diuretics in general and antiepileptics such as oxcarbazepine.

Storage instructions:

Do not store above 25°C. Do not freeze. Store in the outer container.
 

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